2E-3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropenoic acid ethyl ester

Base Information

Chemical Name:2E-3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropenoic acid ethyl ester
CAS No.:275817-02-2
Molecular Formula:C₂₈H₂₈O₆
Molecular Weight:460.527
Hs Code.:

Synonyms:2E-3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropenoic acid ethyl ester

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Chemical Property of 2E-3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropenoic acid ethyl ester

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Technology Process of 2E-3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropenoic acid ethyl ester

There total 10 articles about 2E-3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropenoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 275817-01-1
4,6-dimethoxy-2-benzoyl-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran

: 275817-02-2
2E-3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropenoic acid ethyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 80 ℃; for 3h;
DOI:10.3987/com-99-8839

Reference yield:

: phenylmagnesium bromide

: 275817-02-2
2E-3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropenoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / tetrahydrofuran / 0.5 h / 0 °C

2: 100 percent / TPAP; NMO; 4 Angstroem MS / CH₂Cl₂ / 1 h / 20 °C

3: 100 percent / NaH / tetrahydrofuran / 3 h / 80 °C

With N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 Angstroem MS; sodium hydride; In tetrahydrofuran; dichloromethane; 1: Grignard reaction / 2: Oxidation / 3: Wadsworth-Emmons reaction;
DOI:10.3987/com-99-8839

Reference yield:

: 275816-99-4
4,6-dimethoxy-2-formyl-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran

: 275817-02-2
2E-3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropenoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / tetrahydrofuran / 0.5 h / 0 °C

2: 100 percent / TPAP; NMO; 4 Angstroem MS / CH₂Cl₂ / 1 h / 20 °C

3: 100 percent / NaH / tetrahydrofuran / 3 h / 80 °C

With N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 Angstroem MS; sodium hydride; In tetrahydrofuran; dichloromethane; 1: Grignard reaction / 2: Oxidation / 3: Wadsworth-Emmons reaction;
DOI:10.3987/com-99-8839