3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropanal

Base Information

Chemical Name:3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropanal
CAS No.:275817-04-4
Molecular Formula:C₂₆H₂₆O₅
Molecular Weight:418.489
Hs Code.:

Synonyms:3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropanal

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Chemical Property of 3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropanal

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Technology Process of 3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropanal

There total 12 articles about 3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 275817-03-3
3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropanoic acid ethyl ester

: 275817-04-4
3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropanal

Guidance literature:: With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃; for 0.333333h;
DOI:10.3987/com-99-8839

Reference yield:

: phenylmagnesium bromide

: 275817-04-4
3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropanal

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / tetrahydrofuran / 0.5 h / 0 °C

2: 100 percent / TPAP; NMO; 4 Angstroem MS / CH₂Cl₂ / 1 h / 20 °C

3: 100 percent / NaH / tetrahydrofuran / 3 h / 80 °C

4: 100 percent / H₂ / 10 percent Pd/C / ethyl acetate / 4 h / 20 °C

5: 100 percent / DIBALH / CH₂Cl₂; hexane / 0.33 h / -78 °C

With N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 Angstroem MS; hydrogen; sodium hydride; diisobutylaluminium hydride; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate; 1: Grignard reaction / 2: Oxidation / 3: Wadsworth-Emmons reaction / 4: Catalytic hydrogenation / 5: Reduction;
DOI:10.3987/com-99-8839

Reference yield:

: 275816-99-4
4,6-dimethoxy-2-formyl-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran

: 275817-04-4
3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropanal

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / tetrahydrofuran / 0.5 h / 0 °C

2: 100 percent / TPAP; NMO; 4 Angstroem MS / CH₂Cl₂ / 1 h / 20 °C

3: 100 percent / NaH / tetrahydrofuran / 3 h / 80 °C

4: 100 percent / H₂ / 10 percent Pd/C / ethyl acetate / 4 h / 20 °C

5: 100 percent / DIBALH / CH₂Cl₂; hexane / 0.33 h / -78 °C

With N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 Angstroem MS; hydrogen; sodium hydride; diisobutylaluminium hydride; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate; 1: Grignard reaction / 2: Oxidation / 3: Wadsworth-Emmons reaction / 4: Catalytic hydrogenation / 5: Reduction;
DOI:10.3987/com-99-8839