3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropanoic acid ethyl ester

Base Information

Chemical Name:3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropanoic acid ethyl ester
CAS No.:275817-03-3
Molecular Formula:C₂₈H₃₀O₆
Molecular Weight:462.543
Hs Code.:

Synonyms:3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropanoic acid ethyl ester

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Chemical Property of 3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropanoic acid ethyl ester

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Technology Process of 3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropanoic acid ethyl ester

There total 11 articles about 3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 275817-02-2
2E-3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropenoic acid ethyl ester

: 275817-03-3
3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropanoic acid ethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 4h;
DOI:10.3987/com-99-8839

Reference yield:

: phenylmagnesium bromide

: 275817-03-3
3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / tetrahydrofuran / 0.5 h / 0 °C

2: 100 percent / TPAP; NMO; 4 Angstroem MS / CH₂Cl₂ / 1 h / 20 °C

3: 100 percent / NaH / tetrahydrofuran / 3 h / 80 °C

4: 100 percent / H₂ / 10 percent Pd/C / ethyl acetate / 4 h / 20 °C

With N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 Angstroem MS; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; 1: Grignard reaction / 2: Oxidation / 3: Wadsworth-Emmons reaction / 4: Catalytic hydrogenation;
DOI:10.3987/com-99-8839

Reference yield:

: 275816-97-2
4,6-dimethoxy-2-(4-methoxyphenyl)-2-vinyl-2,3-dihydrobenzofuran

: 275817-03-3
3-[4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-2-yl]-3-phenylpropanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / aq. OsO₄; NMO / tetrahydrofuran / 20 h / 20 °C

2: 96 percent / aq. NaIO₄ / tetrahydrofuran / 1 h / 20 °C

3: 72 percent / tetrahydrofuran / 0.5 h / 0 °C

4: 100 percent / TPAP; NMO; 4 Angstroem MS / CH₂Cl₂ / 1 h / 20 °C

5: 100 percent / NaH / tetrahydrofuran / 3 h / 80 °C

6: 100 percent / H₂ / 10 percent Pd/C / ethyl acetate / 4 h / 20 °C

With sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 Angstroem MS; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; 1: Oxidation / 2: Oxidation / 3: Grignard reaction / 4: Oxidation / 5: Wadsworth-Emmons reaction / 6: Catalytic hydrogenation;
DOI:10.3987/com-99-8839