6-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenyloxy)benzoxazol-2-ylamine

Base Information

Chemical Name:6-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenyloxy)benzoxazol-2-ylamine
CAS No.:433226-27-8
Molecular Formula:C₂₁H₁₄F₄N₄O₃
Molecular Weight:446.361
Hs Code.:

Synonyms:6-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenyloxy)benzoxazol-2-ylamine

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Chemical Property of 6-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenyloxy)benzoxazol-2-ylamine

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Technology Process of 6-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenyloxy)benzoxazol-2-ylamine

There total 5 articles about 6-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenyloxy)benzoxazol-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 433226-24-5
4-(3-benzyloxy-4-nitrophenoxy)aniline

: 433226-27-8
6-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenyloxy)benzoxazol-2-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / tetrahydrofuran / 20 °C

2: H₂ / Pd/C / methanol

3: 237 mg / methanol / 96 h / 20 °C

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm0611051

Reference yield:

: 433226-26-7
N-(4-(3-benzyloxy-4-nitrophenoxy)phenyl)(2-fluoro-5-(trifluoromethyl)phenylamino)formamide

: 433226-27-8
6-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenyloxy)benzoxazol-2-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol

2: 237 mg / methanol / 96 h / 20 °C

With hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1021/jm0611051

Reference yield:

: 446-36-6
5-fluoro-2-nitrophenol

: 433226-27-8
6-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenyloxy)benzoxazol-2-ylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / NaH / dimethylformamide / 20 - 80 °C

2: 100 percent / tetrahydrofuran / 20 °C

3: H₂ / Pd/C / methanol

4: 237 mg / methanol / 96 h / 20 °C

With hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0611051