433226-24-5

Basic information

• Product Name: 4-(3-benzyloxy-4-nitrophenoxy)aniline
• Synonyms: 4-(3-benzyloxy-4-nitrophenoxy)aniline
• CAS NO: 433226-24-5
• Molecular Weight: 336.347
• Mol File: 433226-24-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(3-benzyloxy-4-nitrophenoxy)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-benzyloxy-4-nitrophenoxy)aniline(433226-24-5)
• EPA Substance Registry System: 4-(3-benzyloxy-4-nitrophenoxy)aniline(433226-24-5)

Safety Data

• Hazardous Substances Data: 433226-24-5(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 446-36-6 5-fluoro-2-nitrophenol 
• 123-30-8 4-amino-phenol 
• 129464-01-3 2-(benzyloxy)-4-fluoro-1-nitrobenzene 

Downstream Products

• 433226-26-7 N-(4-(3-benzyloxy-4-nitrophenoxy)phenyl)(2-fluoro-5-(trifluoromethyl)phenylamino)formamide 
• 433226-27-8 6-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenyloxy)benzoxazol-2-ylamine 

Relevant articles and documents

Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors

We herein disclose a novel chemical series of benzimidazole-ureas as inhibitors of VEGFR-2 and TIE-2 kinase receptors, both of which are implicated in angiogenesis. Structure-activity relationship (SAR) studies elucidated a critical role for the N1 nitrogen of both the benzimidazole (segment E) and urea (segment B) moieties. The SAR results were also supported by the X-ray crystallographic elucidation of the role of the N1 nitrogen and the urea moiety when the benzimidazole-urea compounds were bound to the VEGFR-2 enzyme. The left side phenyl ring (segment A) occupies the backpocket where a 3-hydrophobic substituent was favored for TIE-2 activity.