(4-tert-butoxycarbonylamino-cyclohexyl)-carbamic acid phenyl ester

Base Information

• Chemical Name: (4-tert-butoxycarbonylamino-cyclohexyl)-carbamic acid phenyl ester
• CAS No.: 1011483-31-0
• Molecular Formula: C₁₈H₂₆N₂O₄
• Molecular Weight: 334.415
• Mol file: 1011483-31-0.mol

Synonyms:(4-tert-butoxycarbonylamino-cyclohexyl)-carbamic acid phenyl ester

Chemical Property of (4-tert-butoxycarbonylamino-cyclohexyl)-carbamic acid phenyl ester

Chemical Property:

• Boiling Point: 460.0±38.0 °C(Predicted)
• Density: 1.14±0.1 g/cm3(Predicted)

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-tert-butoxycarbonylamino-cyclohexyl)-carbamic acid phenyl ester

There total 1 articles about (4-tert-butoxycarbonylamino-cyclohexyl)-carbamic acid phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (4-aminocyclohexyl)carbamate (195314-59-1) + phenyl chloroformate (1885-14-9) → (4-tert-butoxycarbonylamino-cyclohexyl)-carbamic acid phenyl ester (1011483-31-0)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

(4-tert-butoxycarbonylamino-cyclohexyl)-carbamic acid phenyl ester (1011483-31-0) + (R)-1-benzyl-3-aminopyrrolidine (114715-39-8) → {4-[3-((R)-1-benzyl-pyrrolidin-3-yl)-ureido]-cyclohexyl}-carbamic acid tert-butyl ester (1011733-33-7)

Guidance literature:

In methanol; at 100 ℃; for 0.5h; Microwave irradiation;

Reference yield:

(4-tert-butoxycarbonylamino-cyclohexyl)-carbamic acid phenyl ester (1011483-31-0) + 3-N-tert-butoxycarbonyl-3-(R)-aminopyrrolidine (122536-77-0,140629-77-2) → [(R)-1-(4-tert-butoxycarbonylamino-cyclohexylcarbamoyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester (1108177-74-7)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 1h;

upstream raw materials:

tert-butyl (4-aminocyclohexyl)carbamate

phenyl chloroformate

Downstream raw materials:

[(R)-1-(4-tert-butoxycarbonylamino-cyclohexylcarbamoyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester

{4-[3-((R)-1-benzyl-pyrrolidin-3-yl)-ureido]-cyclohexyl}-carbamic acid tert-butyl ester

[4-((R)-3-Pyrrolidin-3-ylureido)-cyclohexyl]-carbamic acid tert-butyl ester