2-{[3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-7-yl]oxy}acetamide hydrochloride

Base Information

Chemical Name:2-{[3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-7-yl]oxy}acetamide hydrochloride
CAS No.:447418-43-1
Molecular Formula:C₂₂H₂₅N₃O₃*ClH
Molecular Weight:415.92
Hs Code.:

Synonyms:2-{[3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-7-yl]oxy}acetamide hydrochloride

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Chemical Property of 2-{[3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-7-yl]oxy}acetamide hydrochloride

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Technology Process of 2-{[3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-7-yl]oxy}acetamide hydrochloride

There total 12 articles about 2-{[3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-7-yl]oxy}acetamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 447425-71-0
tert-butyl {[7-(2-amino-2-oxoethoxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}carbamate

: 447418-43-1
2-{[3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-7-yl]oxy}acetamide hydrochloride

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 20 ℃; for 15h;
DOI:10.1016/j.bmc.2011.06.059

Reference yield:

: C₂₇H₂₄ClNO₃

: 447418-43-1
2-{[3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-7-yl]oxy}acetamide hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 1 h / 0 °C

2: thionyl chloride / toluene / 2 h / Reflux

3: N,N-dimethyl-formamide / 6 h / 20 °C

4: hydrazine hydrate / ethanol / 1 h / Reflux

5: tetrahydrofuran / 1 h / 20 °C

6: 5%-palladium/activated carbon; hydrogen / tetrahydrofuran; ethanol / 2 h / 20 °C

7: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 10 h / 80 °C

8: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 15 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; 5%-palladium/activated carbon; hydrogen; hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.06.059

Reference yield:

: 447425-66-3
2-{[7-(benzyloxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}-1H-isoindole-1,3(2H)-dione

: 447418-43-1
2-{[3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-7-yl]oxy}acetamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazine hydrate / ethanol / 1 h / Reflux

2: tetrahydrofuran / 1 h / 20 °C

3: 5%-palladium/activated carbon; hydrogen / tetrahydrofuran; ethanol / 2 h / 20 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 10 h / 80 °C

5: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 15 h / 20 °C

With hydrogenchloride; 5%-palladium/activated carbon; hydrogen; hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.06.059