2-{[7-(benzyloxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}-1H-isoindole-1,3(2H)-dione

Base Information

Chemical Name:2-{[7-(benzyloxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}-1H-isoindole-1,3(2H)-dione
CAS No.:447425-66-3
Molecular Formula:C₃₅H₃₀N₂O₄
Molecular Weight:542.634
Hs Code.:

Synonyms:2-{[7-(benzyloxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}-1H-isoindole-1,3(2H)-dione

Suppliers and Price of 2-{[7-(benzyloxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}-1H-isoindole-1,3(2H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-{[7-(benzyloxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}-1H-isoindole-1,3(2H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-{[7-(benzyloxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}-1H-isoindole-1,3(2H)-dione

There total 8 articles about 2-{[7-(benzyloxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}-1H-isoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 447425-65-2
7-(benzyloxy)-3-(chloromethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one

: 1074-82-4
potassium phtalimide

: 447425-66-3
2-{[7-(benzyloxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}-1H-isoindole-1,3(2H)-dione

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 6h;
DOI:10.1016/j.bmc.2011.06.059

Reference yield:

: C₂₇H₂₄ClNO₃

: 447425-66-3
2-{[7-(benzyloxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}-1H-isoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 1 h / 0 °C

2: thionyl chloride / toluene / 2 h / Reflux

3: N,N-dimethyl-formamide / 6 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; In tetrahydrofuran; 1,2-dimethoxyethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.06.059

Reference yield:

: 447425-62-9
C₂₉H₂₉NO₄

: 447425-66-3
2-{[7-(benzyloxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}-1H-isoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / tetrahydrofuran; ethanol; water / 3 h / Reflux

2: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 20 °C

3: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 1 h / 0 °C

4: thionyl chloride / toluene / 2 h / Reflux

5: N,N-dimethyl-formamide / 6 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; oxalyl dichloride; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.06.059