tert-butyl {[7-(2-amino-2-oxoethoxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}carbamate

Base Information

Chemical Name:tert-butyl {[7-(2-amino-2-oxoethoxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}carbamate
CAS No.:447425-71-0
Molecular Formula:C₂₇H₃₃N₃O₅
Molecular Weight:479.576
Hs Code.:

Synonyms:tert-butyl {[7-(2-amino-2-oxoethoxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}carbamate

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Chemical Property of tert-butyl {[7-(2-amino-2-oxoethoxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}carbamate

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Technology Process of tert-butyl {[7-(2-amino-2-oxoethoxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}carbamate

There total 11 articles about tert-butyl {[7-(2-amino-2-oxoethoxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 144-48-9
iodacetamide

: 447425-68-5
tert-butyl {[7-hydroxy-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}carbamate

: 447425-71-0
tert-butyl {[7-(2-amino-2-oxoethoxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}carbamate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 80 ℃; for 10h;
DOI:10.1016/j.bmc.2011.06.059

Reference yield:

: C₂₇H₂₄ClNO₃

: 447425-71-0
tert-butyl {[7-(2-amino-2-oxoethoxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 1 h / 0 °C

2: thionyl chloride / toluene / 2 h / Reflux

3: N,N-dimethyl-formamide / 6 h / 20 °C

4: hydrazine hydrate / ethanol / 1 h / Reflux

5: tetrahydrofuran / 1 h / 20 °C

6: 5%-palladium/activated carbon; hydrogen / tetrahydrofuran; ethanol / 2 h / 20 °C

7: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 10 h / 80 °C

With sodium tetrahydroborate; thionyl chloride; 5%-palladium/activated carbon; hydrogen; hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.06.059

Reference yield:

: 447425-62-9
C₂₉H₂₉NO₄

: 447425-71-0
tert-butyl {[7-(2-amino-2-oxoethoxy)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}carbamate

Guidance literature:: Multi-step reaction with 9 steps

1: sodium hydroxide / tetrahydrofuran; ethanol; water / 3 h / Reflux

2: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 20 °C

3: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 1 h / 0 °C

4: thionyl chloride / toluene / 2 h / Reflux

5: N,N-dimethyl-formamide / 6 h / 20 °C

6: hydrazine hydrate / ethanol / 1 h / Reflux

7: tetrahydrofuran / 1 h / 20 °C

8: 5%-palladium/activated carbon; hydrogen / tetrahydrofuran; ethanol / 2 h / 20 °C

9: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 10 h / 80 °C

With sodium tetrahydroborate; thionyl chloride; oxalyl dichloride; 5%-palladium/activated carbon; hydrogen; hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.06.059