2-chloro-N-(2,3-dimethylphenyl)acetamide

Base Information

• Chemical Name: 2-chloro-N-(2,3-dimethylphenyl)acetamide
• CAS No.: 2564-07-0
• Molecular Formula: C10H12ClNO
• Molecular Weight: 197.664
• Hs Code.: 2924299090
• NSC Number: 166431
• DSSTox Substance ID: DTXSID20304597
• Nikkaji Number: J1.395.866A
• Wikidata: Q82050620
• Mol file: 2564-07-0.mol

Synonyms:2-chloro-N-(2,3-dimethylphenyl)acetamide;2564-07-0;2-Chloro-N-(2,3-dimethyl-phenyl)-acetamide;2-chloro-n-(2,3-dimethyl-phenyl)acetamide;MFCD00018895;N-(2,3-dimethylphenyl)-2-chloroacetamide;2-Chloro-2',3'-acetoxylidide;Acetamide,2-chloro-N-(2,3-dimethylphenyl)-;NSC166431;Acetamide, 2-chloro-N-(2,3-dimethylphenyl)-;SCHEMBL4002461;DTXSID20304597;JS-202C;STK115919;AKOS000266283;NSC-166431;NCGC00336753-01;BB 0243233;CS-0116495;FT-0634368;EN300-01790;D83888;AB01330520-02;AT-057/40164814;J-509049;Z56755217

Chemical Property of 2-chloro-N-(2,3-dimethylphenyl)acetamide

Chemical Property:

• Vapor Pressure: 0.00014mmHg at 25°C
• Melting Point: 135-136
• Refractive Index: 1.575
• Boiling Point: 333.1 °C at 760 mmHg
• PKA: 12.91±0.70(Predicted)
• Flash Point: 155.2 °C
• PSA: 29.10000
• Density: 1.187 g/cm³
• LogP: 2.55370
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 197.0607417
• Heavy Atom Count: 13
• Complexity: 184

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-N-(2,3-dimethylphenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=CC=C1)NC(=O)CCl)C
• Uses: 2-Chloro-N-(2,3-dimethylphenyl)acetamide has been used as a reactant in the preparation of quinoxalinyl thioether derivatives with antibacterial and antifungal activity.

Technology Process of 2-chloro-N-(2,3-dimethylphenyl)acetamide

There total 4 articles about 2-chloro-N-(2,3-dimethylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

chloroacetyl chloride (79-04-9) + 2,3-Dimethylaniline (87-59-2) → 2-chloro-N-(2, 3-dimethylphenyl)acetamide (2564-07-0)

Guidance literature:

With sodium hydroxide; In dichloromethane; water; for 18h;

Reference yield: 96.0%

2,3-Dimethylaniline (87-59-2) → 2-chloro-N-(2, 3-dimethylphenyl)acetamide (2564-07-0)

Guidance literature:

Reference yield:

4-amino-o-xylene (95-64-7) + chloroacetyl chloride (79-04-9) → 2-chloro-N-(2, 3-dimethylphenyl)acetamide (2564-07-0)

Guidance literature:

With triethylamine; In dichloromethane; Cooling with ice;

upstream raw materials:

chloroacetyl chloride

2,3-Dimethylaniline

4-amino-o-xylene

Downstream raw materials:

piperidino-acetic acid-(2,3-dimethyl-anilide)

1-[(2,3-dimethyl-phenylcarbamoyl)-methyl]-pyridinium; chloride

2-(diethylamino)-N-(2,3-dimethyl-phenyl)acetamide

N-(2,3-Dimethyl-phenyl)-2-(4-oxo-4H-quinazolin-3-yl)-acetamide