(7S)-2-chloro-7-[(3-fluorobenzyl)oxy]-6,7-dihydro-5H-cyclopenta[b]pyridine

Base Information

Chemical Name:(7S)-2-chloro-7-[(3-fluorobenzyl)oxy]-6,7-dihydro-5H-cyclopenta[b]pyridine
CAS No.:911405-93-1
Molecular Formula:C₁₅H₁₃ClFNO
Molecular Weight:277.726
Hs Code.:

Synonyms:(7S)-2-chloro-7-[(3-fluorobenzyl)oxy]-6,7-dihydro-5H-cyclopenta[b]pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (7S)-2-chloro-7-[(3-fluorobenzyl)oxy]-6,7-dihydro-5H-cyclopenta[b]pyridine

Chemical Property:

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Technology Process of (7S)-2-chloro-7-[(3-fluorobenzyl)oxy]-6,7-dihydro-5H-cyclopenta[b]pyridine

There total 1 articles about (7S)-2-chloro-7-[(3-fluorobenzyl)oxy]-6,7-dihydro-5H-cyclopenta[b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 911405-98-6
(S)-2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridin-7-ol

: 456-41-7
1-(Bromomethyl)-3-fluorobenzene

: 911405-93-1
(7S)-2-chloro-7-[(3-fluorobenzyl)oxy]-6,7-dihydro-5H-cyclopenta[b]pyridine

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 911405-93-1
(7S)-2-chloro-7-[(3-fluorobenzyl)oxy]-6,7-dihydro-5H-cyclopenta[b]pyridine

: 163765-44-4
(R)-tert-butyl 3-methylpiperazine-1-carboxylate

: 911405-95-3
C₂₅H₃₂FN₃O₃

Guidance literature:: With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; Heating / reflux;

Reference yield:

: 911405-93-1
(7S)-2-chloro-7-[(3-fluorobenzyl)oxy]-6,7-dihydro-5H-cyclopenta[b]pyridine

: (7S)-7-[(3-fluorobenzyl)oxy]-2-[(2R)-2-methylpiperazin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / Heating / reflux

2: trifluoroacetic acid / dichloromethane / 20 °C

With trifluoroacetic acid; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In dichloromethane; toluene;