1-(5-bromo-4-chloro-2-fluoro-benzenesulfonyl)-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline

Base Information

Chemical Name:1-(5-bromo-4-chloro-2-fluoro-benzenesulfonyl)-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline
CAS No.:1070973-15-7
Molecular Formula:C₁₇H₁₆BrClFNO₂S
Molecular Weight:432.741
Hs Code.:

Synonyms:1-(5-bromo-4-chloro-2-fluoro-benzenesulfonyl)-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline

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Chemical Property of 1-(5-bromo-4-chloro-2-fluoro-benzenesulfonyl)-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline

Chemical Property:

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Technology Process of 1-(5-bromo-4-chloro-2-fluoro-benzenesulfonyl)-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline

There total 6 articles about 1-(5-bromo-4-chloro-2-fluoro-benzenesulfonyl)-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20364-31-2
4,4-dimethyl-1,2,3,4-tetrahydroquinoline

: 1070972-67-6
5-bromo-4-chloro-2-fluoro-benzenesulfonyl chloride

: 1070973-15-7
1-(5-bromo-4-chloro-2-fluoro-benzenesulfonyl)-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 88h; Product distribution / selectivity;

Reference yield:

: 3350-78-5
3,3-Dimethylacryloyl chloride

: 1070973-15-7
1-(5-bromo-4-chloro-2-fluoro-benzenesulfonyl)-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

2.1: aluminum (III) chloride / dichloromethane / 2 h / 50 °C

2.2: 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 50 °C

3.2: 0.17 h / 20 °C

4.1: sodium hydrogencarbonate / water; acetonitrile / 3 h

With lithium aluminium tetrahydride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; aluminum (III) chloride; In tetrahydrofuran; dichloromethane; water; acetonitrile;

Reference yield:

: 13209-80-8
N-phenyl-3-methyl-2-butenamide

: 1070973-15-7
1-(5-bromo-4-chloro-2-fluoro-benzenesulfonyl)-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: aluminum (III) chloride / dichloromethane / 2 h / 50 °C

1.2: 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 50 °C

2.2: 0.17 h / 20 °C

3.1: sodium hydrogencarbonate / water; acetonitrile / 3 h

With lithium aluminium tetrahydride; sodium hydrogencarbonate; aluminum (III) chloride; In tetrahydrofuran; dichloromethane; water; acetonitrile;