3-cyclobutyl-1-(2,6-dimethyl-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester

Base Information

• Chemical Name: 3-cyclobutyl-1-(2,6-dimethyl-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester
• CAS No.: 1280201-09-3
• Molecular Formula: C₁₈H₂₃NO₃
• Molecular Weight: 301.386
• Mol file: 1280201-09-3.mol

Synonyms:3-cyclobutyl-1-(2,6-dimethyl-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester

Chemical Property of 3-cyclobutyl-1-(2,6-dimethyl-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 3-cyclobutyl-1-(2,6-dimethyl-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester

There total 4 articles about 3-cyclobutyl-1-(2,6-dimethyl-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclobutyl iodide (38557-29-8) + 1-(2,6-dimethylphenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester (1280200-63-6) → 3-cyclobutyl-1-(2,6-dimethyl-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester (1280201-09-3)

Guidance literature:

1-(2,6-dimethylphenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -50 - 0 ℃;

cyclobutyl iodide; In tetrahydrofuran; at -50 - 20 ℃; for 2h;

Reference yield:

2-methylenesuccinic acid (97-65-4,25119-64-6) → 3-cyclobutyl-1-(2,6-dimethyl-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester (1280201-09-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 0.75 h / 130 °C

2.1: acetyl chloride / 1 h / 64 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / -50 - 0 °C

3.2: 2 h / -50 - 20 °C

With acetyl chloride; lithium hexamethyldisilazane; In tetrahydrofuran;

Reference yield:

2,6-dimethylaniline (87-62-7) → 3-cyclobutyl-1-(2,6-dimethyl-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester (1280201-09-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 0.75 h / 130 °C

2.1: acetyl chloride / 1 h / 64 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / -50 - 0 °C

3.2: 2 h / -50 - 20 °C

With acetyl chloride; lithium hexamethyldisilazane; In tetrahydrofuran;

upstream raw materials:

2-methylenesuccinic acid

2,6-dimethylaniline

cyclobutyl iodide

1-(2,6-dimethylphenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester

Downstream raw materials:

3-cyclobutyl-1-(2,6-dimethylphenyl)-5-oxo-pyrrolidine-3-carboxylic acid (3,5-bis-trifluoromethylphenyl)amide