1-(2,6-dimethylphenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester

Base Information

• Chemical Name: 1-(2,6-dimethylphenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester
• CAS No.: 1280200-63-6
• Molecular Formula: C₁₄H₁₇NO₃
• Molecular Weight: 247.294
• Mol file: 1280200-63-6.mol

Synonyms:1-(2,6-dimethylphenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester

Chemical Property of 1-(2,6-dimethylphenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-(2,6-dimethylphenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester

There total 3 articles about 1-(2,6-dimethylphenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + 1-(2,6-dimethyl-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid (63674-48-6) + trimethyl orthoformate (149-73-5) → 1-(2,6-dimethylphenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester (1280200-63-6)

Guidance literature:

With acetyl chloride; at 64 ℃; for 1h;

Reference yield:

2,6-dimethylaniline (87-62-7) → 1-(2,6-dimethylphenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester (1280200-63-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.75 h / 130 °C

2: acetyl chloride / 1 h / 64 °C

With acetyl chloride;

Reference yield:

2-methylenesuccinic acid (97-65-4,25119-64-6) → 1-(2,6-dimethylphenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester (1280200-63-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.75 h / 130 °C

2: acetyl chloride / 1 h / 64 °C

With acetyl chloride;

upstream raw materials:

2-methylenesuccinic acid

2,6-dimethylaniline

methanol

1-(2,6-dimethyl-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid

Downstream raw materials:

1-(2,6-dimethylphenyl)-3-methyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester

1-(2,6-dimethylphenyl)-3,4-dimethyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester

methyl 2-(2,6-dimethylphenyl)-1-oxooctahydrocyclopenta[c]pyrrole-3a-carboxylate

C₁₆H₂₁NO₄