(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

Base Information

Chemical Name:(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide
CAS No.:1401624-28-9
Molecular Formula:C₂₅H₃₁N₅O₃S
Molecular Weight:481.619
Hs Code.:

Synonyms:(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

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Technology Process of (S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

There total 14 articles about (S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1401624-73-4
Boc-(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

: 1401624-28-9
(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

Guidance literature:: Boc-(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide; With formic acid; at 20 ℃; for 4h;

With sodium hydrogencarbonate; In water;

Reference yield:

: C₃₀H₃₉N₅O₅S

: 1401624-28-9
(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

Guidance literature:: With formic acid; at 20 ℃; for 4h;
DOI:10.1016/j.bcp.2019.04.006

Reference yield:

: methyl 1-amino-2-[4'-(4-methylplperailn-1-yI-sulfonyl)-biphenyl-4-yl]cyclopropanecarboxylate

: 1401624-28-9
(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 1 h / 0 °C

1.2: 20 °C

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C

2.2: pH 3

3.1: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 1 h / 0 °C

3.2: 20 °C

4.1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 4 h / 20 °C

5.1: formic acid / 4 h / 20 °C

With 4-methyl-morpholine; formic acid; 1,3,5-trichloro-2,4,6-triazine; lithium hydroxide monohydrate; water; chloroformic acid ethyl ester; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;