Boc-(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

Base Information

Chemical Name:Boc-(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide
CAS No.:1401624-73-4
Molecular Formula:C₃₀H₃₉N₅O₅S
Molecular Weight:581.736
Hs Code.:

Synonyms:Boc-(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

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Chemical Property of Boc-(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

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Technology Process of Boc-(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

There total 4 articles about Boc-(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1401624-71-2
tert-butyl (S)-1-((1R,2R)-1-carbamoyl-2-(4'-(4-methylpiperazin-1-yl-sulfonyl)biphenyl-4-yl)cyclopropylamino)-1-oxobutan-2-ylcarbamate

: 1401624-73-4
Boc-(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

Guidance literature:: With 1,3,5-trichloro-2,4,6-triazine; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: methyl 1-amino-2-[4'-(4-methylplperailn-1-yI-sulfonyl)-biphenyl-4-yl]cyclopropanecarboxylate

: 1401624-73-4
Boc-(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 1 h / 0 °C

1.2: 20 °C

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C

2.2: pH 3

3.1: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 1 h / 0 °C

3.2: 20 °C

4.1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 4 h / 20 °C

With 4-methyl-morpholine; 1,3,5-trichloro-2,4,6-triazine; lithium hydroxide monohydrate; water; chloroformic acid ethyl ester; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1401624-69-8
(1R,2R)-methyl ((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl4-yl)cyclopropanecarboxylate

: 1401624-73-4
Boc-(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)butanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C

1.2: pH 3

2.1: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 1 h / 0 °C

2.2: 20 °C

3.1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 4 h / 20 °C

With 4-methyl-morpholine; 1,3,5-trichloro-2,4,6-triazine; lithium hydroxide monohydrate; water; chloroformic acid ethyl ester; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;