tert-butyl (S)-1-((1R,2R)-1-carbamoyl-2-(4'-(4-methylpiperazin-1-yl-sulfonyl)biphenyl-4-yl)cyclopropylamino)-1-oxobutan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl (S)-1-((1R,2R)-1-carbamoyl-2-(4'-(4-methylpiperazin-1-yl-sulfonyl)biphenyl-4-yl)cyclopropylamino)-1-oxobutan-2-ylcarbamate
CAS No.:1401624-71-2
Molecular Formula:C₃₀H₄₁N₅O₆S
Molecular Weight:599.751
Hs Code.:

Synonyms:tert-butyl (S)-1-((1R,2R)-1-carbamoyl-2-(4'-(4-methylpiperazin-1-yl-sulfonyl)biphenyl-4-yl)cyclopropylamino)-1-oxobutan-2-ylcarbamate

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Chemical Property of tert-butyl (S)-1-((1R,2R)-1-carbamoyl-2-(4'-(4-methylpiperazin-1-yl-sulfonyl)biphenyl-4-yl)cyclopropylamino)-1-oxobutan-2-ylcarbamate

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Technology Process of tert-butyl (S)-1-((1R,2R)-1-carbamoyl-2-(4'-(4-methylpiperazin-1-yl-sulfonyl)biphenyl-4-yl)cyclopropylamino)-1-oxobutan-2-ylcarbamate

There total 2 articles about tert-butyl (S)-1-((1R,2R)-1-carbamoyl-2-(4'-(4-methylpiperazin-1-yl-sulfonyl)biphenyl-4-yl)cyclopropylamino)-1-oxobutan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₄₀N₄O₇S

: 1401624-71-2
tert-butyl (S)-1-((1R,2R)-1-carbamoyl-2-(4'-(4-methylpiperazin-1-yl-sulfonyl)biphenyl-4-yl)cyclopropylamino)-1-oxobutan-2-ylcarbamate

Guidance literature:: C₃₀H₄₀N₄O₇S; With 4-methyl-morpholine; chloroformic acid ethyl ester; In dichloromethane; at 0 ℃; for 1h;

With ammonia; In dichloromethane; water; at 20 ℃;

Reference yield:

: 1401624-69-8
(1R,2R)-methyl ((S)-2-(tert-butoxycarbonylamino)butanamido)-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl4-yl)cyclopropanecarboxylate

: 1401624-71-2
tert-butyl (S)-1-((1R,2R)-1-carbamoyl-2-(4'-(4-methylpiperazin-1-yl-sulfonyl)biphenyl-4-yl)cyclopropylamino)-1-oxobutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C

1.2: pH 3

2.1: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 1 h / 0 °C

2.2: 20 °C

With 4-methyl-morpholine; lithium hydroxide monohydrate; water; chloroformic acid ethyl ester; In tetrahydrofuran; dichloromethane;