(S)-methyl 2-((S)-3-(3-iodo-4-methoxyphenyl)-2-(4-methylphenylsulfonamido)propylamino)-3-(4-methoxyphenyl)propanoate

Base Information

Chemical Name:(S)-methyl 2-((S)-3-(3-iodo-4-methoxyphenyl)-2-(4-methylphenylsulfonamido)propylamino)-3-(4-methoxyphenyl)propanoate
CAS No.:1264149-55-4
Molecular Formula:C₂₈H₃₃IN₂O₆S
Molecular Weight:652.55
Hs Code.:

Synonyms:(S)-methyl 2-((S)-3-(3-iodo-4-methoxyphenyl)-2-(4-methylphenylsulfonamido)propylamino)-3-(4-methoxyphenyl)propanoate

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Chemical Property of (S)-methyl 2-((S)-3-(3-iodo-4-methoxyphenyl)-2-(4-methylphenylsulfonamido)propylamino)-3-(4-methoxyphenyl)propanoate

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Technology Process of (S)-methyl 2-((S)-3-(3-iodo-4-methoxyphenyl)-2-(4-methylphenylsulfonamido)propylamino)-3-(4-methoxyphenyl)propanoate

There total 9 articles about (S)-methyl 2-((S)-3-(3-iodo-4-methoxyphenyl)-2-(4-methylphenylsulfonamido)propylamino)-3-(4-methoxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1264149-52-1
(S)-2-(3-iodo-4-methoxybenzyl)-1-tosylaziridine

: 7479-01-8
O-methyl-L-tyrosine methyl ester hydrochloride

: 1264149-55-4
(S)-methyl 2-((S)-3-(3-iodo-4-methoxyphenyl)-2-(4-methylphenylsulfonamido)propylamino)-3-(4-methoxyphenyl)propanoate

Guidance literature:: (S)-2-(3-iodo-4-methoxybenzyl)-1-tosylaziridine; O-methyl-L-tyrosine methyl ester hydrochloride; With triethylamine; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

With boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 - 60 ℃;
DOI:10.1002/asia.201000554

Reference yield:

: 4326-36-7
(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

: 1264149-55-4
(S)-methyl 2-((S)-3-(3-iodo-4-methoxyphenyl)-2-(4-methylphenylsulfonamido)propylamino)-3-(4-methoxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h

2.1: iodine; silver sulfate / methanol / 2 h / 25 °C

3.1: hydrogenchloride; water / methanol / 0.5 h / 20 °C

4.1: triethylamine / dichloromethane / 0 - 25 °C

5.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

7.1: triethylamine / tetrahydrofuran / 0.08 h / 0 °C

7.2: 0 - 60 °C

With hydrogenchloride; lithium borohydride; water; iodine; potassium carbonate; silver sulfate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 6.1: Mitsunobu cyclization;
DOI:10.1002/asia.201000554

Reference yield:

: 3417-91-2
L-tyrosine methyl ester HCl

: 1264149-55-4
(S)-methyl 2-((S)-3-(3-iodo-4-methoxyphenyl)-2-(4-methylphenylsulfonamido)propylamino)-3-(4-methoxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydrogencarbonate / ethanol / 2 h

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h

3.1: iodine; silver sulfate / methanol / 2 h / 25 °C

4.1: hydrogenchloride; water / methanol / 0.5 h / 20 °C

5.1: triethylamine / dichloromethane / 0 - 25 °C

6.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

7.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

8.1: triethylamine / tetrahydrofuran / 0.08 h / 0 °C

8.2: 0 - 60 °C

With hydrogenchloride; lithium borohydride; water; iodine; sodium hydrogencarbonate; potassium carbonate; silver sulfate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 7.1: Mitsunobu cyclization;
DOI:10.1002/asia.201000554