(S)-methyl 3-(3-iodo-4-methoxyphenyl)-2-(4-methylphenylsulfonamido)propanoate

Base Information

Chemical Name:(S)-methyl 3-(3-iodo-4-methoxyphenyl)-2-(4-methylphenylsulfonamido)propanoate
CAS No.:1264149-46-3
Molecular Formula:C₁₈H₂₀INO₅S
Molecular Weight:489.331
Hs Code.:

Synonyms:(S)-methyl 3-(3-iodo-4-methoxyphenyl)-2-(4-methylphenylsulfonamido)propanoate

Suppliers and Price of (S)-methyl 3-(3-iodo-4-methoxyphenyl)-2-(4-methylphenylsulfonamido)propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-methyl 3-(3-iodo-4-methoxyphenyl)-2-(4-methylphenylsulfonamido)propanoate

Chemical Property:

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Technology Process of (S)-methyl 3-(3-iodo-4-methoxyphenyl)-2-(4-methylphenylsulfonamido)propanoate

There total 5 articles about (S)-methyl 3-(3-iodo-4-methoxyphenyl)-2-(4-methylphenylsulfonamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 98778-86-0
methyl (S)-2-amino-3-(3-iodo-4-methoxyphenyl)propanoate hydrochloride

: 1264149-46-3
(S)-methyl 3-(3-iodo-4-methoxyphenyl)-2-(4-methylphenylsulfonamido)propanoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 25 ℃;
DOI:10.1002/asia.201000554

Reference yield:

: 4326-36-7
(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

: 1264149-46-3
(S)-methyl 3-(3-iodo-4-methoxyphenyl)-2-(4-methylphenylsulfonamido)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h

2: iodine; silver sulfate / methanol / 2 h / 25 °C

3: hydrogenchloride; water / methanol / 0.5 h / 20 °C

4: triethylamine / dichloromethane / 0 - 25 °C

With hydrogenchloride; water; iodine; potassium carbonate; silver sulfate; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/asia.201000554

Reference yield:

: 3417-91-2
L-tyrosine methyl ester HCl

: 1264149-46-3
(S)-methyl 3-(3-iodo-4-methoxyphenyl)-2-(4-methylphenylsulfonamido)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / ethanol / 2 h

2: potassium carbonate / N,N-dimethyl-formamide / 2 h

3: iodine; silver sulfate / methanol / 2 h / 25 °C

4: hydrogenchloride; water / methanol / 0.5 h / 20 °C

5: triethylamine / dichloromethane / 0 - 25 °C

With hydrogenchloride; water; iodine; sodium hydrogencarbonate; potassium carbonate; silver sulfate; triethylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/asia.201000554