N-((S)-1-(N-((S)-1-hydroxy-3-(4-methoxyphenyl)propan-2-yl)methylsulfonamido)-3-(3-iodo-4-methoxyphenyl)propan-2-yl)-4-methylbenzenesulfonamide

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Chemical Name:N-((S)-1-(N-((S)-1-hydroxy-3-(4-methoxyphenyl)propan-2-yl)methylsulfonamido)-3-(3-iodo-4-methoxyphenyl)propan-2-yl)-4-methylbenzenesulfonamide
CAS No.:1264149-61-2
Molecular Formula:C₂₈H₃₅IN₂O₇S₂
Molecular Weight:702.632
Hs Code.:

Synonyms:N-((S)-1-(N-((S)-1-hydroxy-3-(4-methoxyphenyl)propan-2-yl)methylsulfonamido)-3-(3-iodo-4-methoxyphenyl)propan-2-yl)-4-methylbenzenesulfonamide

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Chemical Property of N-((S)-1-(N-((S)-1-hydroxy-3-(4-methoxyphenyl)propan-2-yl)methylsulfonamido)-3-(3-iodo-4-methoxyphenyl)propan-2-yl)-4-methylbenzenesulfonamide

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Technology Process of N-((S)-1-(N-((S)-1-hydroxy-3-(4-methoxyphenyl)propan-2-yl)methylsulfonamido)-3-(3-iodo-4-methoxyphenyl)propan-2-yl)-4-methylbenzenesulfonamide

There total 11 articles about N-((S)-1-(N-((S)-1-hydroxy-3-(4-methoxyphenyl)propan-2-yl)methylsulfonamido)-3-(3-iodo-4-methoxyphenyl)propan-2-yl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1264149-58-7
(S)-methyl 2-(N-((S)-3-(3-iodo-4-methoxyphenyl)-2-(4-methylphenylsulfonamido)propyl)methylsulfonamido)-3-(4-methoxyphenyl)propanoate

: 1264149-61-2
N-((S)-1-(N-((S)-1-hydroxy-3-(4-methoxyphenyl)propan-2-yl)methylsulfonamido)-3-(3-iodo-4-methoxyphenyl)propan-2-yl)-4-methylbenzenesulfonamide

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1002/asia.201000554

Reference yield:

: 4326-36-7
(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

: 1264149-61-2
N-((S)-1-(N-((S)-1-hydroxy-3-(4-methoxyphenyl)propan-2-yl)methylsulfonamido)-3-(3-iodo-4-methoxyphenyl)propan-2-yl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h

2.1: iodine; silver sulfate / methanol / 2 h / 25 °C

3.1: hydrogenchloride; water / methanol / 0.5 h / 20 °C

4.1: triethylamine / dichloromethane / 0 - 25 °C

5.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

7.1: triethylamine / tetrahydrofuran / 0.08 h / 0 °C

7.2: 0 - 60 °C

8.1: pyridine / 0 - 20 °C

9.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

With pyridine; hydrogenchloride; lithium borohydride; water; iodine; potassium carbonate; silver sulfate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 6.1: Mitsunobu cyclization;
DOI:10.1002/asia.201000554

Reference yield:

: 3417-91-2
L-tyrosine methyl ester HCl

: 1264149-61-2
N-((S)-1-(N-((S)-1-hydroxy-3-(4-methoxyphenyl)propan-2-yl)methylsulfonamido)-3-(3-iodo-4-methoxyphenyl)propan-2-yl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydrogencarbonate / ethanol / 2 h

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h

3.1: iodine; silver sulfate / methanol / 2 h / 25 °C

4.1: hydrogenchloride; water / methanol / 0.5 h / 20 °C

5.1: triethylamine / dichloromethane / 0 - 25 °C

6.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

7.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

8.1: triethylamine / tetrahydrofuran / 0.08 h / 0 °C

8.2: 0 - 60 °C

9.1: pyridine / 0 - 20 °C

10.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

With pyridine; hydrogenchloride; lithium borohydride; water; iodine; sodium hydrogencarbonate; potassium carbonate; silver sulfate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 7.1: Mitsunobu cyclization;
DOI:10.1002/asia.201000554