(R)-N-(1-(4-(2-bromoethoxy)phenyl)propan-2-yl)-N-methylprop-2-yn-1-amine

Base Information

• Chemical Name: (R)-N-(1-(4-(2-bromoethoxy)phenyl)propan-2-yl)-N-methylprop-2-yn-1-amine
• CAS No.: 1430326-06-9
• Molecular Formula: C₁₅H₂₀BrNO
• Molecular Weight: 310.234
• Mol file: 1430326-06-9.mol

Synonyms:(R)-N-(1-(4-(2-bromoethoxy)phenyl)propan-2-yl)-N-methylprop-2-yn-1-amine

Chemical Property of (R)-N-(1-(4-(2-bromoethoxy)phenyl)propan-2-yl)-N-methylprop-2-yn-1-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-(1-(4-(2-bromoethoxy)phenyl)propan-2-yl)-N-methylprop-2-yn-1-amine

There total 7 articles about (R)-N-(1-(4-(2-bromoethoxy)phenyl)propan-2-yl)-N-methylprop-2-yn-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.2%

ethylene dibromide (106-93-4) + (R)-4-(2-(methyl(prop-2-ynyl)amino)propyl)phenol → (R)-N-(1-(4-(2-bromoethoxy)phenyl)propan-2-yl)-N-methylprop-2-yn-1-amine (1430326-06-9)

Guidance literature:

With potassium carbonate; potassium iodide; In acetonitrile; for 16h; Inert atmosphere; Reflux;

DOI:10.1016/j.ejmech.2013.01.039

Reference yield:

[2-(4-methoxy-phenyl)-1-methyl-ethyl]-(1-phenyl-ethyl)-amine → (R)-N-(1-(4-(2-bromoethoxy)phenyl)propan-2-yl)-N-methylprop-2-yn-1-amine (1430326-06-9)

Guidance literature:

Multi-step reaction with 6 steps

1: L-Tartaric acid / ethanol

2: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 40 °C / 1.5?MPa

3: potassium carbonate / toluene; acetonitrile / 16 h / 20 °C / Inert atmosphere

4: formic acid / 12 h / 90 °C

5: boron tribromide / dichloromethane / -20 - 20 °C / Inert atmosphere

6: potassium carbonate; potassium iodide / acetonitrile / 16 h / Inert atmosphere; Reflux

With formic acid; L-Tartaric acid; palladium 10% on activated carbon; hydrogen; boron tribromide; potassium carbonate; potassium iodide; In methanol; ethanol; dichloromethane; toluene; acetonitrile;

DOI:10.1016/j.ejmech.2013.01.039

Reference yield:

(R)-N-(1-(4-methoxyphenyl)propan-2-yl)prop-2-yn-1-amine (1430326-04-7) → (R)-N-(1-(4-(2-bromoethoxy)phenyl)propan-2-yl)-N-methylprop-2-yn-1-amine (1430326-06-9)

Guidance literature:

Multi-step reaction with 3 steps

1: formic acid / 12 h / 90 °C

2: boron tribromide / dichloromethane / -20 - 20 °C / Inert atmosphere

3: potassium carbonate; potassium iodide / acetonitrile / 16 h / Inert atmosphere; Reflux

With formic acid; boron tribromide; potassium carbonate; potassium iodide; In dichloromethane; acetonitrile;

DOI:10.1016/j.ejmech.2013.01.039

upstream raw materials:

(R)-N-(1-(4-methoxyphenyl)propan-2-yl)prop-2-yn-1-amine

(R)-N-(1-(4-methoxyphenyl)propan-2-yl)-N-methylprop-2-yn-1-amine

ethylene dibromide

(R)-1-(4-methoxyphenyl)-N-((R)-1-phenylethyl)propan-2-amine

Downstream raw materials:

(R)-N-(2-(4-(2-(methyl(prop-2-ynyl)amino)propyl)phenoxy)ethyl)-1,2,3,4-tetrahydroacridin-9-amine