N-{5-[6-(4-methoxyphenyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-yl}-2-pyrrolidin-1-ylacetamide

Base Information

Chemical Name:N-{5-[6-(4-methoxyphenyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-yl}-2-pyrrolidin-1-ylacetamide
CAS No.:1469857-92-8
Molecular Formula:C₂₆H₂₅N₅O₂S
Molecular Weight:471.583
Hs Code.:

Synonyms:N-{5-[6-(4-methoxyphenyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-yl}-2-pyrrolidin-1-ylacetamide

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Chemical Property of N-{5-[6-(4-methoxyphenyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-yl}-2-pyrrolidin-1-ylacetamide

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Technology Process of N-{5-[6-(4-methoxyphenyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-yl}-2-pyrrolidin-1-ylacetamide

There total 9 articles about N-{5-[6-(4-methoxyphenyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-yl}-2-pyrrolidin-1-ylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1469858-62-5
N-{5-[6-(4-methoxyphenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-yl}-2-pyrrolidin-1-ylacetamide

: 1469857-92-8
N-{5-[6-(4-methoxyphenyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-yl}-2-pyrrolidin-1-ylacetamide

Guidance literature:: With trifluoroacetic acid; In methanol; at 100 ℃; for 2h;

Reference yield:

: 1469858-46-5
2-bromo-6-(4-methoxyphenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene

: 1469857-92-8
N-{5-[6-(4-methoxyphenyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-yl}-2-pyrrolidin-1-ylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / ethanol; toluene / 8 h / 100 °C

2.1: triethylamine / 1,4-dioxane / 3 h / 20 °C

2.2: 2 h

3.1: trifluoroacetic acid / methanol / 2 h / 100 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; ethanol; toluene;

Reference yield:

: 1469857-45-1
2-bromo-6-(4-methoxyphenyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene

: 1469857-92-8
N-{5-[6-(4-methoxyphenyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-yl}-2-pyrrolidin-1-ylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 80 °C

2.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / ethanol; toluene / 8 h / 100 °C

3.1: triethylamine / 1,4-dioxane / 3 h / 20 °C

3.2: 2 h

4.1: trifluoroacetic acid / methanol / 2 h / 100 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium hydride; sodium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; toluene; mineral oil;