N-{5-[6-(4-methoxyphenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-yl}-2-pyrrolidin-1-ylacetamide

Base Information

Chemical Name:N-{5-[6-(4-methoxyphenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-yl}-2-pyrrolidin-1-ylacetamide
CAS No.:1469858-62-5
Molecular Formula:C₃₂H₃₉N₅O₃SSi
Molecular Weight:601.845
Hs Code.:

N-{5-[6-(4-methoxyphenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-yl}-2-pyrrolidin-1-ylacetamide

Synonyms:N-{5-[6-(4-methoxyphenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-yl}-2-pyrrolidin-1-ylacetamide

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Chemical Property of N-{5-[6-(4-methoxyphenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-yl}-2-pyrrolidin-1-ylacetamide

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Technology Process of N-{5-[6-(4-methoxyphenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-yl}-2-pyrrolidin-1-ylacetamide

There total 10 articles about N-{5-[6-(4-methoxyphenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-yl}-2-pyrrolidin-1-ylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 123-75-1
pyrrolidine

: 1469858-61-4
5-[6-(4-methoxyphenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-ylamine

: 79-04-9
chloroacetyl chloride

: 1469858-62-5
N-{5-[6-(4-methoxyphenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-yl}-2-pyrrolidin-1-ylacetamide

Guidance literature:: 5-[6-(4-methoxyphenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-ylamine; chloroacetyl chloride; With triethylamine; In 1,4-dioxane; at 20 ℃; for 3h;

pyrrolidine; In 1,4-dioxane; for 2h;

Reference yield:

: 1469857-45-1
2-bromo-6-(4-methoxyphenyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene

: 1469858-62-5
N-{5-[6-(4-methoxyphenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-yl}-2-pyrrolidin-1-ylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 80 °C

2.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / ethanol; toluene / 8 h / 100 °C

3.1: triethylamine / 1,4-dioxane / 3 h / 20 °C

3.2: 2 h

With bis-triphenylphosphine-palladium(II) chloride; sodium hydride; sodium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; toluene; mineral oil;

Reference yield:

: 4181-97-9
phenyl 4-methoxybenzoate

: 1469858-62-5
N-{5-[6-(4-methoxyphenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-yl}-2-pyrrolidin-1-ylacetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 8 h / 100 °C

2.1: hydrazine hydrate; acetic acid / ethanol / 4 h / 100 °C / Inert atmosphere

3.1: acetic acid; bromine / 12 h / 80 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 80 °C

5.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / ethanol; toluene / 8 h / 100 °C

6.1: triethylamine / 1,4-dioxane / 3 h / 20 °C

6.2: 2 h

With bis-triphenylphosphine-palladium(II) chloride; bromine; sodium hydride; sodium carbonate; hydrazine hydrate; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; toluene; mineral oil;