7-chloro-N-[3-methyl-4-(4-methylpiperazin-1-yl)-5-(morpholin-4-ylmethyl)phenyl]quinolin-4-amine

Base Information

Chemical Name:7-chloro-N-[3-methyl-4-(4-methylpiperazin-1-yl)-5-(morpholin-4-ylmethyl)phenyl]quinolin-4-amine
CAS No.:1312290-92-8
Molecular Formula:C₂₆H₃₂ClN₅O
Molecular Weight:466.026
Hs Code.:

Synonyms:7-chloro-N-[3-methyl-4-(4-methylpiperazin-1-yl)-5-(morpholin-4-ylmethyl)phenyl]quinolin-4-amine

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Chemical Property of 7-chloro-N-[3-methyl-4-(4-methylpiperazin-1-yl)-5-(morpholin-4-ylmethyl)phenyl]quinolin-4-amine

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Technology Process of 7-chloro-N-[3-methyl-4-(4-methylpiperazin-1-yl)-5-(morpholin-4-ylmethyl)phenyl]quinolin-4-amine

There total 8 articles about 7-chloro-N-[3-methyl-4-(4-methylpiperazin-1-yl)-5-(morpholin-4-ylmethyl)phenyl]quinolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 86-98-6,1138471-54-1
4,7-dichloroquinoline

: 1312290-94-0
3-methyl-4-(4-methylpiperazin-1-yl)-5-(morpholin-4-ylmethyl)aniline

: 1312290-92-8
7-chloro-N-[3-methyl-4-(4-methylpiperazin-1-yl)-5-(morpholin-4-ylmethyl)phenyl]quinolin-4-amine

Guidance literature:: 4,7-dichloroquinoline; 3-methyl-4-(4-methylpiperazin-1-yl)-5-(morpholin-4-ylmethyl)aniline; With hydrogenchloride; In water; acetonitrile; Reflux;

With ammonium hydroxide; In methanol; dichloromethane;

Reference yield:

: 7149-70-4
2-bromo-5-nitrotoluene

: 1312290-92-8
7-chloro-N-[3-methyl-4-(4-methylpiperazin-1-yl)-5-(morpholin-4-ylmethyl)phenyl]quinolin-4-amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: trifluorormethanesulfonic acid / 0.33 h / 0 °C

1.2: 18 h / 0 - 20 °C

2.1: hydrazine hydrate / acetonitrile / Reflux

2.3: pH 10

3.1: tetrahydrofuran

4.1: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

5.1: acetyl chloride; methanol / 2 h / 20 °C

5.2: pH 10

6.1: potassium carbonate; sodium iodide / acetonitrile / 48 h / Reflux

7.1: ammonium formate / palladium 10% on activated carbon / ethanol / 20 °C

8.1: hydrogenchloride / acetonitrile; water / Reflux

With hydrogenchloride; methanol; trifluorormethanesulfonic acid; ammonium formate; potassium carbonate; caesium carbonate; hydrazine hydrate; acetyl chloride; sodium iodide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; ethanol; water; acetonitrile;

Reference yield:

: 1312290-86-0
(2-bromo-3-methyl-5-nitrophenyl)methanamine

: 1312290-92-8
7-chloro-N-[3-methyl-4-(4-methylpiperazin-1-yl)-5-(morpholin-4-ylmethyl)phenyl]quinolin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran

2.1: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

3.1: acetyl chloride; methanol / 2 h / 20 °C

3.2: pH 10

4.1: potassium carbonate; sodium iodide / acetonitrile / 48 h / Reflux

5.1: ammonium formate / palladium 10% on activated carbon / ethanol / 20 °C

6.1: hydrogenchloride / acetonitrile; water / Reflux

With hydrogenchloride; methanol; ammonium formate; potassium carbonate; caesium carbonate; acetyl chloride; sodium iodide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; ethanol; water; acetonitrile;