3-methyl-4-(4-methylpiperazin-1-yl)-5-(morpholin-4-ylmethyl)aniline

Base Information

Chemical Name:3-methyl-4-(4-methylpiperazin-1-yl)-5-(morpholin-4-ylmethyl)aniline
CAS No.:1312290-94-0
Molecular Formula:C₁₇H₂₈N₄O
Molecular Weight:304.436
Hs Code.:

Synonyms:3-methyl-4-(4-methylpiperazin-1-yl)-5-(morpholin-4-ylmethyl)aniline

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Chemical Property of 3-methyl-4-(4-methylpiperazin-1-yl)-5-(morpholin-4-ylmethyl)aniline

Chemical Property:

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Technology Process of 3-methyl-4-(4-methylpiperazin-1-yl)-5-(morpholin-4-ylmethyl)aniline

There total 7 articles about 3-methyl-4-(4-methylpiperazin-1-yl)-5-(morpholin-4-ylmethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1312290-93-9
4-{[3-methyl-2-(4-methylpiperazin-1-yl)-5-nitrophenyl]methyl}morpholine

: 1312290-94-0
3-methyl-4-(4-methylpiperazin-1-yl)-5-(morpholin-4-ylmethyl)aniline

Guidance literature:: With ammonium formate; palladium 10% on activated carbon; In ethanol; at 20 ℃;

Reference yield:

: 7149-70-4
2-bromo-5-nitrotoluene

: 1312290-94-0
3-methyl-4-(4-methylpiperazin-1-yl)-5-(morpholin-4-ylmethyl)aniline

Guidance literature:: Multi-step reaction with 7 steps

1.1: trifluorormethanesulfonic acid / 0.33 h / 0 °C

1.2: 18 h / 0 - 20 °C

2.1: hydrazine hydrate / acetonitrile / Reflux

2.3: pH 10

3.1: tetrahydrofuran

4.1: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

5.1: acetyl chloride; methanol / 2 h / 20 °C

5.2: pH 10

6.1: potassium carbonate; sodium iodide / acetonitrile / 48 h / Reflux

7.1: ammonium formate / palladium 10% on activated carbon / ethanol / 20 °C

With methanol; trifluorormethanesulfonic acid; ammonium formate; potassium carbonate; caesium carbonate; hydrazine hydrate; acetyl chloride; sodium iodide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; ethanol; acetonitrile;

Reference yield:

: 1312290-85-9
2-[(2-bromo-3-methyl-5-nitrophenyl)methyl]-2,3-dihydro-1H-isoindole-1,3-dione

: 1312290-94-0
3-methyl-4-(4-methylpiperazin-1-yl)-5-(morpholin-4-ylmethyl)aniline

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrazine hydrate / acetonitrile / Reflux

1.3: pH 10

2.1: tetrahydrofuran

3.1: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

4.1: acetyl chloride; methanol / 2 h / 20 °C

4.2: pH 10

5.1: potassium carbonate; sodium iodide / acetonitrile / 48 h / Reflux

6.1: ammonium formate / palladium 10% on activated carbon / ethanol / 20 °C

With methanol; ammonium formate; potassium carbonate; caesium carbonate; hydrazine hydrate; acetyl chloride; sodium iodide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; ethanol; acetonitrile;