Technology Process of 1-benzyl-5-(5-fluoro-pyridin-3-yl)-8-hydroxy-2-oxo-1,2-dihydro-[1,6]naphthyridine-7-carboxylic acid methyl ester
There total 10 articles about 1-benzyl-5-(5-fluoro-pyridin-3-yl)-8-hydroxy-2-oxo-1,2-dihydro-[1,6]naphthyridine-7-carboxylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
caesium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
N,N-dimethyl-formamide;
at 100 ℃;
for 16h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 10 steps
1: thionyl chloride / 5 h / -20 °C / Reflux
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C
3: trichlorophosphate / N,N-dimethyl-formamide / 1 h / 0 °C / Cooling with ice
4: dichloro-acetic acid / water / 1 h / Reflux
5: potassium carbonate; lithium bromide; tetrabutylammomium bromide / toluene; water / 0.67 h / 80 °C
6: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux
7: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C
8: sodium methylate / methanol / Cooling with ice
9: N-Bromosuccinimide / dichloromethane / 3 h / Reflux
10: caesium carbonate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere
With
dichloro-acetic acid; N-Bromosuccinimide; thionyl chloride; tetrabutylammomium bromide; sodium methylate; potassium carbonate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium iodide; lithium bromide; trichlorophosphate; dibenzoyl peroxide;
tetrakis(triphenylphosphine) palladium(0);
In
methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C
2: trichlorophosphate / N,N-dimethyl-formamide / 1 h / 0 °C / Cooling with ice
3: dichloro-acetic acid / water / 1 h / Reflux
4: potassium carbonate; lithium bromide; tetrabutylammomium bromide / toluene; water / 0.67 h / 80 °C
5: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux
6: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C
7: sodium methylate / methanol / Cooling with ice
8: N-Bromosuccinimide / dichloromethane / 3 h / Reflux
9: caesium carbonate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere
With
dichloro-acetic acid; N-Bromosuccinimide; tetrabutylammomium bromide; sodium methylate; potassium carbonate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium iodide; lithium bromide; trichlorophosphate; dibenzoyl peroxide;
tetrakis(triphenylphosphine) palladium(0);
In
methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
