(RS)-2-trifluoroacetyl-1,2,3,4-tetrahydro-6,7-dimethoxy-1-[4',5'-dimethoxy-2'-(2''-oxoethyl)phenyl]methylisoquinoline

Base Information

Chemical Name:(RS)-2-trifluoroacetyl-1,2,3,4-tetrahydro-6,7-dimethoxy-1-[4',5'-dimethoxy-2'-(2''-oxoethyl)phenyl]methylisoquinoline
CAS No.:1234560-22-5
Molecular Formula:C₂₄H₂₆F₃NO₆
Molecular Weight:481.469
Hs Code.:

Synonyms:(RS)-2-trifluoroacetyl-1,2,3,4-tetrahydro-6,7-dimethoxy-1-[4',5'-dimethoxy-2'-(2''-oxoethyl)phenyl]methylisoquinoline

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Chemical Property of (RS)-2-trifluoroacetyl-1,2,3,4-tetrahydro-6,7-dimethoxy-1-[4',5'-dimethoxy-2'-(2''-oxoethyl)phenyl]methylisoquinoline

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Technology Process of (RS)-2-trifluoroacetyl-1,2,3,4-tetrahydro-6,7-dimethoxy-1-[4',5'-dimethoxy-2'-(2''-oxoethyl)phenyl]methylisoquinoline

There total 1 articles about (RS)-2-trifluoroacetyl-1,2,3,4-tetrahydro-6,7-dimethoxy-1-[4',5'-dimethoxy-2'-(2''-oxoethyl)phenyl]methylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1234560-20-3
2-trifluoroacetyl-1,2,3,4-tetrahydro-1-[2'-(2'',3''-dihydroxypropyl)-4',5'-dimethoxyphenyl]methyl-6,7-dimethoxyisoquinoline

: 1234560-22-5
(RS)-2-trifluoroacetyl-1,2,3,4-tetrahydro-6,7-dimethoxy-1-[4',5'-dimethoxy-2'-(2''-oxoethyl)phenyl]methylisoquinoline

Guidance literature:: With sodium periodate; silica gel; In dichloromethane; water; at 20 ℃; for 1h;
DOI:10.1016/j.tet.2010.03.110

Reference yield: 74.0%

: 123-75-1
pyrrolidine

: 1234560-22-5
(RS)-2-trifluoroacetyl-1,2,3,4-tetrahydro-6,7-dimethoxy-1-[4',5'-dimethoxy-2'-(2''-oxoethyl)phenyl]methylisoquinoline

: 1234560-28-1
(RS)-2-trifluoroacetyl-1,2,3,4-tetrahydro-6,7-dimethoxy-1-[4',5'-dimethoxy-2'-(2''-(N-pyrrolidinyl)ethyl)phenyl]methylisoquinoline

Guidance literature:: pyrrolidine; (RS)-2-trifluoroacetyl-1,2,3,4-tetrahydro-6,7-dimethoxy-1-[4',5'-dimethoxy-2'-(2''-oxoethyl)phenyl]methylisoquinoline; With sodium cyanoborohydride; In acetonitrile; at 20 ℃; for 0.333333h;

With acetic acid; In acetonitrile; at 20 ℃; for 18h; pH=Ca. 6;

With sodium carbonate; In dichloromethane; water;
DOI:10.1016/j.tet.2010.03.110

Reference yield: 68.0%

: 1234560-22-5
(RS)-2-trifluoroacetyl-1,2,3,4-tetrahydro-6,7-dimethoxy-1-[4',5'-dimethoxy-2'-(2''-oxoethyl)phenyl]methylisoquinoline

: 109-89-7
diethylamine

: 1234560-29-2
(RS)-1-[2'-(2''-(diethylamino)ethyl)-4',5'-dimethoxyphenyl]methyl-2-trifluoroacetyl-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

Guidance literature:: (RS)-2-trifluoroacetyl-1,2,3,4-tetrahydro-6,7-dimethoxy-1-[4',5'-dimethoxy-2'-(2''-oxoethyl)phenyl]methylisoquinoline; diethylamine; With sodium cyanoborohydride; In acetonitrile; at 20 ℃; for 0.333333h;

With acetic acid; In acetonitrile; at 20 ℃; for 18h; pH=Ca. 6;

With sodium carbonate; In dichloromethane; water;
DOI:10.1016/j.tet.2010.03.110