2-(1,2,3,4-tetrahydrocarbazol-4-oxo-9-benzenesulfonyl-2-yl)-butanamide

Base Information

Chemical Name:2-(1,2,3,4-tetrahydrocarbazol-4-oxo-9-benzenesulfonyl-2-yl)-butanamide
CAS No.:450408-90-9
Molecular Formula:C₂₂H₂₂N₂O₄S
Molecular Weight:410.494
Hs Code.:

Synonyms:2-(1,2,3,4-tetrahydrocarbazol-4-oxo-9-benzenesulfonyl-2-yl)-butanamide

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Chemical Property of 2-(1,2,3,4-tetrahydrocarbazol-4-oxo-9-benzenesulfonyl-2-yl)-butanamide

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Technology Process of 2-(1,2,3,4-tetrahydrocarbazol-4-oxo-9-benzenesulfonyl-2-yl)-butanamide

There total 6 articles about 2-(1,2,3,4-tetrahydrocarbazol-4-oxo-9-benzenesulfonyl-2-yl)-butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 98-09-9
benzenesulfonyl chloride

: 450408-89-6
2-(1,2,3,4-tetrahydrocarbazol-4-oxo-2-yl)-butanamide

: 450408-90-9
2-(1,2,3,4-tetrahydrocarbazol-4-oxo-9-benzenesulfonyl-2-yl)-butanamide

Guidance literature:: With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1002/jhet.5570390212

Reference yield:

: 930-68-7
cyclohexenone

: 450408-90-9
2-(1,2,3,4-tetrahydrocarbazol-4-oxo-9-benzenesulfonyl-2-yl)-butanamide

Guidance literature:: Multi-step reaction with 6 steps

1: 66 percent / sodium ethylate / ethanol / 16 h / 0 - 20 °C

2: 57 percent / acetic acid / 5 h / Heating

3: 68 percent / aq. sodium chloride; dimethyl sulfoxide / 18 h / 160 °C

4: 52 percent / 2,3-dichloro-5,6-dicyano-p-benzoquinone / tetrahydrofuran / 5 h / 20 °C

5: 75 percent / BF₃*Et₂O; aq. acetic acid / 72 h / Heating

6: 84 percent / aq. sodium hydroxide; tetrabutylammonium hydrogen sulfate / CH₂Cl₂ / 1 h / 20 °C

With sodium hydroxide; boron trifluoride diethyl etherate; sodium ethanolate; tetra(n-butyl)ammonium hydrogensulfate; acetic acid; dimethyl sulfoxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium chloride; In tetrahydrofuran; ethanol; dichloromethane; 1: Michael reaction / 2: Fischer indol reaction;
DOI:10.1002/jhet.5570390212

Reference yield:

: 450408-86-3
ethyl 2-cyano-2-(3-oxo-cyclohexyl)-butanoate

: 450408-90-9
2-(1,2,3,4-tetrahydrocarbazol-4-oxo-9-benzenesulfonyl-2-yl)-butanamide

Guidance literature:: Multi-step reaction with 5 steps

1: 57 percent / acetic acid / 5 h / Heating

2: 68 percent / aq. sodium chloride; dimethyl sulfoxide / 18 h / 160 °C

3: 52 percent / 2,3-dichloro-5,6-dicyano-p-benzoquinone / tetrahydrofuran / 5 h / 20 °C

4: 75 percent / BF₃*Et₂O; aq. acetic acid / 72 h / Heating

5: 84 percent / aq. sodium hydroxide; tetrabutylammonium hydrogen sulfate / CH₂Cl₂ / 1 h / 20 °C

With sodium hydroxide; boron trifluoride diethyl etherate; tetra(n-butyl)ammonium hydrogensulfate; acetic acid; dimethyl sulfoxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium chloride; In tetrahydrofuran; dichloromethane; 1: Fischer indol reaction;
DOI:10.1002/jhet.5570390212