(2R)-2-[(3'-fluoro-4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]-4-[4-oxo-7-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]butyl benzoate

Base Information

Chemical Name:(2R)-2-[(3'-fluoro-4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]-4-[4-oxo-7-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]butyl benzoate
CAS No.:1369963-34-7
Molecular Formula:C₃₃H₂₈F₄N₄O₆S
Molecular Weight:684.668
Hs Code.:

Synonyms:(2R)-2-[(3'-fluoro-4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]-4-[4-oxo-7-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]butyl benzoate

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Chemical Property of (2R)-2-[(3'-fluoro-4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]-4-[4-oxo-7-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]butyl benzoate

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Technology Process of (2R)-2-[(3'-fluoro-4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]-4-[4-oxo-7-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]butyl benzoate

There total 5 articles about (2R)-2-[(3'-fluoro-4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]-4-[4-oxo-7-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]butyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 106-40-1
4-bromo-aniline

: 1369963-34-7
(2R)-2-[(3'-fluoro-4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]-4-[4-oxo-7-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]butyl benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 1 h

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 0 °C

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 110 °C

4: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 20 °C

5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With pyridine; di-isopropyl azodicarboxylate; hydrogen; potassium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 4284-50-8
N-(4-bromophenyl)methanesulfonamide

: 1369963-34-7
(2R)-2-[(3'-fluoro-4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]-4-[4-oxo-7-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]butyl benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 0 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 110 °C

3: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 20 °C

4: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; hydrogen; potassium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: (S)-4-(benzyloxy)-2-hydroxybutyl benzoate

: 1369963-34-7
(2R)-2-[(3'-fluoro-4'-methoxybiphenyl-4-yl)(methylsulfonyl)amino]-4-[4-oxo-7-(trifluoromethyl)-1,2,3-benzotriazin-3(4H)-yl]butyl benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 0 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 110 °C

3: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 20 °C

4: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; hydrogen; potassium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;