(1S,10bS)-1-benzyl-6-(prop-1-en-2-yl)-2-tosyl-1,2,3,10b-tetrahydroindeno[1,2-c]azepin-10b-yl benzoate

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Chemical Name:(1S,10bS)-1-benzyl-6-(prop-1-en-2-yl)-2-tosyl-1,2,3,10b-tetrahydroindeno[1,2-c]azepin-10b-yl benzoate
CAS No.:1383949-89-0
Molecular Formula:C₃₇H₃₃NO₄S
Molecular Weight:587.739
Hs Code.:

Synonyms:(1S,10bS)-1-benzyl-6-(prop-1-en-2-yl)-2-tosyl-1,2,3,10b-tetrahydroindeno[1,2-c]azepin-10b-yl benzoate

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Chemical Property of (1S,10bS)-1-benzyl-6-(prop-1-en-2-yl)-2-tosyl-1,2,3,10b-tetrahydroindeno[1,2-c]azepin-10b-yl benzoate

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Technology Process of (1S,10bS)-1-benzyl-6-(prop-1-en-2-yl)-2-tosyl-1,2,3,10b-tetrahydroindeno[1,2-c]azepin-10b-yl benzoate

There total 5 articles about (1S,10bS)-1-benzyl-6-(prop-1-en-2-yl)-2-tosyl-1,2,3,10b-tetrahydroindeno[1,2-c]azepin-10b-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1383949-66-3
(2S,3S)-6-methyl-2-(4-methyl-N-(prop-2-yn-1-yl)phenylsulfonamido)-1,3-diphenylhept-6-en-4-yn-3-yl benzoate

: 1383949-89-0
(1S,10bS)-1-benzyl-6-(prop-1-en-2-yl)-2-tosyl-1,2,3,10b-tetrahydroindeno[1,2-c]azepin-10b-yl benzoate

Guidance literature:: With Echavarren's catalyst; In toluene; at 120 ℃; for 20h; chemoselective reaction; Molecular sieve; Inert atmosphere;
DOI:10.1021/ja304964s

Reference yield:

: 98-88-4
benzoyl chloride

: 1383949-89-0
(1S,10bS)-1-benzyl-6-(prop-1-en-2-yl)-2-tosyl-1,2,3,10b-tetrahydroindeno[1,2-c]azepin-10b-yl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; triethylamine / dichloromethane / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3: Echavarren's catalyst / toluene / 20 h / 120 °C / Molecular sieve; Inert atmosphere

With dmap; Echavarren's catalyst; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja304964s

Reference yield:

: 78-80-8
2-methylbut-1-en-3-yne

: 1383949-89-0
(1S,10bS)-1-benzyl-6-(prop-1-en-2-yl)-2-tosyl-1,2,3,10b-tetrahydroindeno[1,2-c]azepin-10b-yl benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

1.2: 10 h / -78 - 20 °C

2.1: dmap; triethylamine / dichloromethane / 0 - 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

4.1: Echavarren's catalyst / toluene / 20 h / 120 °C / Molecular sieve; Inert atmosphere

With dmap; Echavarren's catalyst; potassium carbonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja304964s