1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone

Base Information

• Chemical Name: 1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone
• CAS No.: 1190865-44-1
• Molecular Formula: C₈H₂Cl₂F₄O
• Molecular Weight: 261.003
• Hs Code.: 2914790090
• Mol file: 1190865-44-1.mol

Synonyms:1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one

Chemical Property of 1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone

Chemical Property:

• Vapor Pressure: 20-2750Pa at 20-37.8℃
• Boiling Point: 282.5±40.0 °C(Predicted)
• Density: 1.577±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

3',5'-Dichloro-2,2,2,4'-tetrafluoroacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone can be used as a pesticide intermediate, mainly in the synthesis of sarolaner.

Technology Process of 1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone

There total 30 articles about 1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.2%

→ 1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one (1190865-44-1)

Guidance literature:

With magnesium; In tetrahydrofuran; ethylene dibromide; at 20 ℃; for 6h;

In tetrahydrofuran; ethylene dibromide; at 20 ℃; for 1.33333h;

Reference yield: 85.1%

N,N-diethyl-2,2,2-trifluoroacetamide (360-92-9) + 5-bromo-1,3-dichloro-2-fluorobenzene (17318-08-0) → 1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one (1190865-44-1)

Guidance literature:

5-bromo-1,3-dichloro-2-fluorobenzene; With magnesium; In tetrahydrofuran; ethylene dibromide; at 20 ℃; for 6h;

N,N-diethyl-2,2,2-trifluoroacetamide; In tetrahydrofuran; ethylene dibromide; at 20 ℃; for 1.33333h;

Reference yield: 82.0%

2-fluoro-3-chloro-5-trifluoroacetylaniline → 1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one (1190865-44-1)

Guidance literature:

2-fluoro-3-chloro-5-trifluoroacetylaniline; With nitrosylsulfuric acid; sulfuric acid; at 45 ℃; for 1h;

With hydrogenchloride; copper(l) chloride; In water; at 40 - 50 ℃; for 2h; Temperature;

upstream raw materials:

ethyl trifluoroacetate,

1,3-dichloro-2-fluoro-5-iodo-benzene

3,5-dichloro-4-fluorophenylamine

2,2,2-trifluoro-1-(4-fluorophenyl)ethanone

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