1,3-Dichloro-2-fluoro-5-iodobenzene

Base Information

• Chemical Name: 1,3-Dichloro-2-fluoro-5-iodobenzene
• CAS No.: 133307-08-1
• Molecular Formula: C6H2Cl2FI
• Molecular Weight: 290.89
• Mol file: 133307-08-1.mol

Synonyms:1,3-Dichloro-2-fluoro-5-iodobenzene;5-Iodo-1,3-dichloro-2-fluorobenzene

Chemical Property of 1,3-Dichloro-2-fluoro-5-iodobenzene

Chemical Property:

• Boiling Point: 261.3±35.0 °C(Predicted)
• PSA: 0.00000
• Density: 2.083±0.06 g/cm3(Predicted)
• LogP: 3.73710
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

3,5-Dichloro-4-fluoroiodobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3,5-Dichloro-4-fluoroiodobenzene, is a reagent used in the synthesis of various chemical compounds.

Technology Process of 1,3-Dichloro-2-fluoro-5-iodobenzene

There total 1 articles about 1,3-Dichloro-2-fluoro-5-iodobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-dichloro-4-fluorophenylamine (2729-34-2) → 1,3-dichloro-2-fluoro-5-iodo-benzene (133307-08-1)

Guidance literature:

3,5-dichloro-4-fluorophenylamine; With sulfuric acid; acetic acid; sodium nitrite; at 20 ℃; for 4h; Cooling with ice;

With potassium iodide; at 70 ℃; for 1h; Cooling with ice;

Reference yield: 53.0%

1,3-dichloro-2-fluoro-5-iodo-benzene (133307-08-1) + N-methoxy-N-methyltrifluoroacetamide (104863-67-4) → 1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one (1190865-44-1)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h;

Reference yield:

1,3-dichloro-2-fluoro-5-iodo-benzene (133307-08-1) → [2-chloro-4-[5-(3,5-dichloro-4-fluoro-phenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]phenyl]-(4,4-difluoro-1-piperidyl)methanone

Guidance literature:

Multi-step reaction with 7 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C

2.1: triethylamine / n-heptane / 70 °C

3.1: thionyl chloride; pyridine / toluene / 5 h / 60 - 80 °C

4.1: triethylamine; hydrogen sulfide / dichloromethane / 1 h / 0 °C

5.1: triethylamine; hydroxylamine-O-sulfonic acid / water; dichloromethane / 1 h / -15 - 0 °C

5.2: 2 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 20 °C

7.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene; dichloromethane / 20 °C

7.2: 66 h / 0 - 20 °C

With pyridine; n-butyllithium; thionyl chloride; oxalyl dichloride; hydrogen sulfide; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; hydroxylamine-O-sulfonic acid; In tetrahydrofuran; hexane; n-heptane; dichloromethane; water; toluene;

upstream raw materials:

3,5-dichloro-4-fluorophenylamine

Downstream raw materials:

1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethan-1-one

Refernces