3-((4-(2-aminopyrazine-5-carbonyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

Base Information

Chemical Name:3-((4-(2-aminopyrazine-5-carbonyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide
CAS No.:1124214-54-5
Molecular Formula:C₂₁H₂₈N₆O₂
Molecular Weight:396.492
Hs Code.:

Synonyms:3-((4-(2-aminopyrazine-5-carbonyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

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Chemical Property of 3-((4-(2-aminopyrazine-5-carbonyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

Chemical Property:

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Technology Process of 3-((4-(2-aminopyrazine-5-carbonyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

There total 11 articles about 3-((4-(2-aminopyrazine-5-carbonyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1124214-52-3
tert-butyl 5-(4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carbonyl)pyrazin-2-ylcarbamate

: 1124214-54-5
3-((4-(2-aminopyrazine-5-carbonyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

Guidance literature:: tert-butyl 5-(4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carbonyl)pyrazin-2-ylcarbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 122-05-4
2,5-pyrazinedicarboxylic acid

: 1124214-54-5
3-((4-(2-aminopyrazine-5-carbonyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride / 48 h / 80 °C / sealed vessel

2.1: hydrazine hydrate / ethanol / 20 °C

3.1: hydrogenchloride; sodium nitrite / dichloromethane; water / 1 h / 0 - 10 °C

4.1: toluene / 1 h / Reflux

5.1: water; potassium hydroxide / methanol / 20 °C

5.2: pH 2

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

6.2: 20 °C

7.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With hydrogenchloride; water; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; potassium hydroxide; sodium nitrite; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1094362-66-9
N-tert-butyl-3-(chloromethyl)benzamide

: 1124214-54-5
3-((4-(2-aminopyrazine-5-carbonyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 °C / Inert atmosphere

2.1: hydrogenchloride / ethanol / 4 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 20 °C

4.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;