3-<1,4-dioxo-4-(phenylmethoxy)-2(S)-<(1-triphenylmethyl-1H-imidazol-4-yl)methyl>butyl>-4(S)-(1-methylethyl)-2-oxazolidinone

Base Information

Chemical Name:3-<1,4-dioxo-4-(phenylmethoxy)-2(S)-<(1-triphenylmethyl-1H-imidazol-4-yl)methyl>butyl>-4(S)-(1-methylethyl)-2-oxazolidinone
CAS No.:160447-12-1
Molecular Formula:C₄₀H₃₉N₃O₅
Molecular Weight:641.767
Hs Code.:

Synonyms:3-<1,4-dioxo-4-(phenylmethoxy)-2(S)-<(1-triphenylmethyl-1H-imidazol-4-yl)methyl>butyl>-4(S)-(1-methylethyl)-2-oxazolidinone

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Chemical Property of 3-<1,4-dioxo-4-(phenylmethoxy)-2(S)-<(1-triphenylmethyl-1H-imidazol-4-yl)methyl>butyl>-4(S)-(1-methylethyl)-2-oxazolidinone

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Technology Process of 3-<1,4-dioxo-4-(phenylmethoxy)-2(S)-<(1-triphenylmethyl-1H-imidazol-4-yl)methyl>butyl>-4(S)-(1-methylethyl)-2-oxazolidinone

There total 1 articles about 3-<1,4-dioxo-4-(phenylmethoxy)-2(S)-<(1-triphenylmethyl-1H-imidazol-4-yl)methyl>butyl>-4(S)-(1-methylethyl)-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 160447-11-0
4(S)-(1-methylethyl)-3-[1-oxo-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propyl]-2-oxazolidinone

: 5437-45-6
Benzyl bromoacetate

: 160447-12-1
3-<1,4-dioxo-4-(phenylmethoxy)-2(S)-<(1-triphenylmethyl-1H-imidazol-4-yl)methyl>butyl>-4(S)-(1-methylethyl)-2-oxazolidinone

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; 1.) 45 min, 2.) 2 h;
DOI:10.1016/S0968-0896(98)00265-X

Reference yield:

: 160447-12-1
3-<1,4-dioxo-4-(phenylmethoxy)-2(S)-<(1-triphenylmethyl-1H-imidazol-4-yl)methyl>butyl>-4(S)-(1-methylethyl)-2-oxazolidinone

: 160447-14-3
2-(1-trityl-1H-imidazol-4-ylmethyl)-succinic acid 4-benzyl ester

Guidance literature:: With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 25 ℃;
DOI:10.1016/S0968-0896(98)00265-X

Reference yield:

: 160447-12-1
3-<1,4-dioxo-4-(phenylmethoxy)-2(S)-<(1-triphenylmethyl-1H-imidazol-4-yl)methyl>butyl>-4(S)-(1-methylethyl)-2-oxazolidinone

: N¹-(1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-N⁴-dimethylcarbamoylmethyl-2-(1H-imidazol-4-ylmethyl)-N⁴-(1-phenyl-ethyl)-succinamide

Guidance literature:: Multi-step reaction with 5 steps

1: 30 percent H₂O₂, LiOH*H₂O / tetrahydrofuran; H₂O / 25 °C

2: i-Pr₂NEt, BOP*PF₆ / dimethylformamide / 25 °C

3: 99 percent / H₂ / Pd/C / ethanol / 2.5 h / 760 Torr

4: 65 percent / BOP*PF₆, i-Pr₂NEt / dimethylformamide / 5 h / 25 °C

5: 48 percent / H₂ / Pd(OH)2/C / ethanol; acetic acid / 41 h / 2585.74 Torr

With lithium hydroxide; hydrogen; dihydrogen peroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(98)00265-X