Technology Process of 3-[3-(benzyloxy)-1,2-oxazol-5-yl]propan-1-ol
There total 4 articles about 3-[3-(benzyloxy)-1,2-oxazol-5-yl]propan-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl (2E)-3-[3-(benzyloxy)-1,2-oxazol-5-yl]acrylate;
With
lithium borohydride;
In
tetrahydrofuran;
at 20 ℃;
for 22h;
Inert atmosphere;
With
hydrogenchloride;
In
tetrahydrofuran; water;
at 20 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / acetone / 1 h / Reflux
2.1: methanol; sodium tetrahydroborate / 20 h / 20 °C
2.2: 2 h / 20 °C
3.1: dipyridinium dichromate / dichloromethane / 16 h / 20 °C
4.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C
4.2: 18 h / 20 °C
5.1: lithium borohydride / tetrahydrofuran / 22 h / 20 °C / Inert atmosphere
5.2: 20 °C / Inert atmosphere
With
methanol; sodium tetrahydroborate; dipyridinium dichromate; lithium borohydride; sodium hydride; potassium carbonate;
In
tetrahydrofuran; dichloromethane; acetone;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: dipyridinium dichromate / dichloromethane / 16 h / 20 °C
2.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C
2.2: 18 h / 20 °C
3.1: lithium borohydride / tetrahydrofuran / 22 h / 20 °C / Inert atmosphere
3.2: 20 °C / Inert atmosphere
With
dipyridinium dichromate; lithium borohydride; sodium hydride;
In
tetrahydrofuran; dichloromethane;
![ethyl (2E)-3-[3-(benzyloxy)-1,2-oxazol-5-yl]acrylate](/Databaselist/images/loading.webp)
