3-tert-butyl-1-(4-{[tert-butyl(dimethyl)silyl]oxy}-3-fluorophenyl)-1H-pyrazol-5-amine

Base Information

Chemical Name:3-tert-butyl-1-(4-{[tert-butyl(dimethyl)silyl]oxy}-3-fluorophenyl)-1H-pyrazol-5-amine
CAS No.:1344738-06-2
Molecular Formula:C₁₉H₃₀FN₃OSi
Molecular Weight:363.551
Hs Code.:

Synonyms:3-tert-butyl-1-(4-{[tert-butyl(dimethyl)silyl]oxy}-3-fluorophenyl)-1H-pyrazol-5-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-tert-butyl-1-(4-{[tert-butyl(dimethyl)silyl]oxy}-3-fluorophenyl)-1H-pyrazol-5-amine

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Technology Process of 3-tert-butyl-1-(4-{[tert-butyl(dimethyl)silyl]oxy}-3-fluorophenyl)-1H-pyrazol-5-amine

There total 3 articles about 3-tert-butyl-1-(4-{[tert-butyl(dimethyl)silyl]oxy}-3-fluorophenyl)-1H-pyrazol-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1344738-08-4
4-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)-2-fluorophenol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1344738-06-2
3-tert-butyl-1-(4-{[tert-butyl(dimethyl)silyl]oxy}-3-fluorophenyl)-1H-pyrazol-5-amine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm200677b

Reference yield:

: C₆H₇FN₂O

: 1344738-06-2
3-tert-butyl-1-(4-{[tert-butyl(dimethyl)silyl]oxy}-3-fluorophenyl)-1H-pyrazol-5-amine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol; water / 16 h / 60 °C / Inert atmosphere

2: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With 1H-imidazole; hydrogenchloride; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm200677b

Reference yield:

: 59997-51-2
trimethylacetylacetonitrile

: 1344738-06-2
3-tert-butyl-1-(4-{[tert-butyl(dimethyl)silyl]oxy}-3-fluorophenyl)-1H-pyrazol-5-amine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol; water / 16 h / 60 °C / Inert atmosphere

2: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With 1H-imidazole; hydrogenchloride; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm200677b