4-(4-methylpiperazin-1-ylmethyl)-N-[3-(4-methylpiperazin-1-ylmethyl)phenyl]benzamide

Base Information

Chemical Name:4-(4-methylpiperazin-1-ylmethyl)-N-[3-(4-methylpiperazin-1-ylmethyl)phenyl]benzamide
CAS No.:1350443-59-2
Molecular Formula:C₂₅H₃₅N₅O
Molecular Weight:421.586
Hs Code.:

Synonyms:4-(4-methylpiperazin-1-ylmethyl)-N-[3-(4-methylpiperazin-1-ylmethyl)phenyl]benzamide

Suppliers and Price of 4-(4-methylpiperazin-1-ylmethyl)-N-[3-(4-methylpiperazin-1-ylmethyl)phenyl]benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 4-(4-methylpiperazin-1-ylmethyl)-N-[3-(4-methylpiperazin-1-ylmethyl)phenyl]benzamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-(4-methylpiperazin-1-ylmethyl)-N-[3-(4-methylpiperazin-1-ylmethyl)phenyl]benzamide

There total 7 articles about 4-(4-methylpiperazin-1-ylmethyl)-N-[3-(4-methylpiperazin-1-ylmethyl)phenyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 4-((4-methylpiperazin-1-yl)methyl)benzoyl chloride dihydrochloride

: 198281-55-9
3-(4-methyl-piperazin-1-ylmethyl)-phenylamine

: 1350443-59-2
4-(4-methylpiperazin-1-ylmethyl)-N-[3-(4-methylpiperazin-1-ylmethyl)phenyl]benzamide

Guidance literature:: 3-(4-methyl-piperazin-1-ylmethyl)-phenylamine; With triethylamine; In tetrahydrofuran; at 20 ℃;

4-((4-methylpiperazin-1-yl)methyl)benzoyl chloride dihydrochloride; In tetrahydrofuran; at 0 - 50 ℃; for 17h;
DOI:10.1134/S1070428011100198

Reference yield:

: C₁₉H₂₁N₅O₂

: 198281-55-9
3-(4-methyl-piperazin-1-ylmethyl)-phenylamine

: 1350443-59-2
4-(4-methylpiperazin-1-ylmethyl)-N-[3-(4-methylpiperazin-1-ylmethyl)phenyl]benzamide

Guidance literature:: With dmap; In dichloromethane; at 18 - 25 ℃; for 30h;
DOI:10.1134/S1070428011100198

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1350443-59-2
4-(4-methylpiperazin-1-ylmethyl)-N-[3-(4-methylpiperazin-1-ylmethyl)phenyl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate; acetic acid

2.1: hydrazine hydrate

3.1: triethylamine / tetrahydrofuran / 20 °C

3.2: 17 h / 0 - 50 °C

With sodium tetrahydroborate; hydrazine hydrate; acetic acid; triethylamine; In tetrahydrofuran;
DOI:10.1134/S1070428011100198