198281-55-9

Basic information

• Product Name: 3-(4-METHYL-PIPERAZIN-1-YLMETHYL)-ANILINE
• Synonyms: 3-(4-METHYL-PIPERAZIN-1-YLMETHYL)-PHENYLAMINE;3-(4-METHYL-PIPERAZIN-1-YLMETHYL)-ANILINE;TIMTEC-BB SBB007471;Benzenamine, 3-[(4-methyl-1-piperazinyl)methyl]-
• CAS NO: 198281-55-9
• Molecular Formula: C₁₂H₁₉N₃
• Molecular Weight: 205.3
• Mol File: 198281-55-9.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-METHYL-PIPERAZIN-1-YLMETHYL)-ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-METHYL-PIPERAZIN-1-YLMETHYL)-ANILINE(198281-55-9)
• EPA Substance Registry System: 3-(4-METHYL-PIPERAZIN-1-YLMETHYL)-ANILINE(198281-55-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 198281-55-9(Hazardous Substances Data)

Usage

Uses

3-[(4-Methylpiperazin-1-yl)methyl]aniline is used in preparation of pyrido[3,4-d]pyrimidin-4-ol derivs. as histone demethylase inhibitors.

Upstream product

• 1015484-22-6 1-methyl-4-((trifluoro-λ⁴-boranyl)methyl)piperazine potassium 
• 108-42-9 3-chloro-aniline 
• 619-23-8 3-Nitrobenzyl chloride 
• 3958-57-4 1-bromomethyl-3-nitrobenzene 
• 109-01-3 1-methyl-piperazine 
• 198281-54-8 1-methyl-4-(3-nitro-benzyl)-piperazine 
• 99-61-6 3-nitro-benzaldehyde 

Downstream Products

• 1350443-59-2 4-(4-methylpiperazin-1-ylmethyl)-N-[3-(4-methylpiperazin-1-ylmethyl)phenyl]benzamide 
• 1429617-80-0 C₂₈H₂₈N₆O 
• 1371209-21-0 C₂₀H₂₄N₄O₃ 
• 943189-22-8 N-methyl-N'-[3-(4-methylpiperazin-1-ylmethyl)phenyl]pyrimidine-4,6-diamine 
• 503183-26-4 4-{[3-((4-methylpiperazin-1-yl)methyl)phenyl]hydrazono}-4H-pyrazole-3,5-diamine 

Relevant articles and documents

Methylpyrazole derivatives as RET inhibitor

The invention relates to a methylpyrazole derivative as an RET inhibitor, in particular to a compound as shown in a formula (I), a stereoisomer and pharmaceutically acceptable salt thereof, a preparation method and a pharmaceutical composition thereof. The compound of the formula (I) can be used for preventing or treating diseases mediated by abnormal RET activity.

2, 4 -DIAMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS

The present invention relates to novel pyrimide derivatives of formula (I): that are useful as kinase inhibitors. More particularly, the present invention relates to novel pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders.

Aminomethylation via cyclopalladated-ferrocenylimine-complexes-catalyzed Suzuki-Miyaura coupling of aryl halides with potassium N, N - dialkylaminomethyltrifluoroborates

Using cyclopalladated ferrocenylimine complexes (1-3 mol%) as catalysts, the Suzuki-Miyaura coupling of potassium N,N-dialkylaminomethyltrifluoroborates with aryl and heteroaryl halides were carried out in a 10:1 THF-H2O mixture at 80° in the presence of Cs2CO3 (3.0 equiv) as base, giving the desired cross-coupling products in 14-87% yields. A variety of potassium alkyltrifluoroborates were also examined. Georg Thieme Verlag Stuttgart New York.