(6-Chloro-5-nitro-pyrimidin-4-yl)-((1S,2R,3S)-2-fluoro-3-trityloxymethyl-cyclopentyl)-amine

Base Information

Chemical Name:(6-Chloro-5-nitro-pyrimidin-4-yl)-((1S,2R,3S)-2-fluoro-3-trityloxymethyl-cyclopentyl)-amine
CAS No.:129746-10-7
Molecular Formula:C₂₉H₂₆ClFN₄O₃
Molecular Weight:533.002
Hs Code.:

Synonyms:(6-Chloro-5-nitro-pyrimidin-4-yl)-((1S,2R,3S)-2-fluoro-3-trityloxymethyl-cyclopentyl)-amine

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Chemical Property of (6-Chloro-5-nitro-pyrimidin-4-yl)-((1S,2R,3S)-2-fluoro-3-trityloxymethyl-cyclopentyl)-amine

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Technology Process of (6-Chloro-5-nitro-pyrimidin-4-yl)-((1S,2R,3S)-2-fluoro-3-trityloxymethyl-cyclopentyl)-amine

There total 10 articles about (6-Chloro-5-nitro-pyrimidin-4-yl)-((1S,2R,3S)-2-fluoro-3-trityloxymethyl-cyclopentyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 4316-93-2
4,6-dichloro-5-nitropyrimidine

: 129746-07-2,129829-84-1,137767-70-5
(1S,2R,3S)-2-Fluoro-3-trityloxymethyl-cyclopentylamine

: 129746-10-7
(6-Chloro-5-nitro-pyrimidin-4-yl)-((1S,2R,3S)-2-fluoro-3-trityloxymethyl-cyclopentyl)-amine

Guidance literature:: With triethylamine; In dichloromethane; Ambient temperature;
DOI:10.1039/c39900000151

Reference yield:

: 119895-90-8
triphenylmethoxymethylcyclopent-2-ene

: 129746-10-7
(6-Chloro-5-nitro-pyrimidin-4-yl)-((1S,2S,3S)-2-fluoro-3-trityloxymethyl-cyclopentyl)-amine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) dimethyldibromohydantoin, 2.) K₂CO₃ / 1.) H₂O, acetone, 0 deg C, 2.) MeOH

2: 84 percent / NaN₃, NH₄Cl / ethanol; H₂O / 90 °C

3: diethylaminosulphur trifluoride (DAST) / CH₂Cl₂ / 0 °C

4: H₂ / Lindlar catalyst / ethanol

5: Et₃N / CH₂Cl₂ / Ambient temperature

With sodium azide; dimethyldibromohydantoin; diethylamino-sulfur trifluoride; hydrogen; potassium carbonate; ammonium chloride; triethylamine; Lindlar's catalyst; In ethanol; dichloromethane; water;
DOI:10.1039/c39900000151

Reference yield:

: 119895-90-8
triphenylmethoxymethylcyclopent-2-ene

: 129746-10-7
(6-Chloro-5-nitro-pyrimidin-4-yl)-((1S,2R,3S)-2-fluoro-3-trityloxymethyl-cyclopentyl)-amine

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) dimethyldibromohydantoin, 2.) K₂CO₃ / 1.) H₂O, acetone, 0 deg C, 2.) MeOH

2: 84 percent / NaN₃, NH₄Cl / ethanol; H₂O / 90 °C

3: pyridine

4: Bu₄NF / tetrahydrofuran

5: 100 percent / H₂ / Lindlar catalyst / ethanol

6: 41 percent / Et₃N / CH₂Cl₂ / Ambient temperature

With pyridine; sodium azide; dimethyldibromohydantoin; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; ammonium chloride; triethylamine; Lindlar's catalyst; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1039/c39900000151