4,5-Diamino-6-hydroxypyrimidine

Base Information

• Chemical Name: 4,5-Diamino-6-hydroxypyrimidine
• CAS No.: 1672-50-0
• Molecular Formula: C4H6N4O
• Molecular Weight: 126.118
• Hs Code.: 29335990
• Mol file: 1672-50-0.mol

Synonyms:4(1H)-Pyrimidinone,5,6-diamino- (9CI);4-Pyrimidinol, 5,6-diamino- (7CI,8CI);4-Hydroxy-5,6-diaminopyrimidine;5,6-Diamino-4(1H)-pyrimidinone;5,6-Diamino-4(3H)-pyrimidinone;5,6-Diamino-4-hydroxypyrimidine;5,6-Diaminopyrimidin-4-ol;NSC 36908;

Chemical Property of 4,5-Diamino-6-hydroxypyrimidine

Chemical Property:

• Appearance/Colour: Pale yellow solid
• Melting Point: 239 °C
• Refractive Index: 2.009
• Boiling Point: 221.5 °C at 760 mmHg
• PKA: 9.92±0.50(Predicted)
• Flash Point: 87.8 °C
• PSA: 97.79000
• Density: 1.84 g/cm³
• LogP: 0.09670
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: Aqueous Base (Slightly), DMSO (Slightly), Water (Very Slightly)

Purity/Quality:

97% ^*data from raw suppliers

5,6-Diamino-4-hydroxypyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A key intermediate in production of HCV (Hepatitis C virus) antivirals.

Technology Process of 4,5-Diamino-6-hydroxypyrimidine

There total 5 articles about 4,5-Diamino-6-hydroxypyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5,6-diamino-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (1004-76-8) → 5,6-diamino-4(3H)-pyrimidinone (1672-50-0)

Guidance literature:

With ammonium hydroxide; In water; for 2h; Reflux;

DOI:10.2174/1570178614666170811123851

Reference yield:

5,6-diamino-3H-pyrimidin-4-one hemisulfonate (102783-18-6) → 4,5-diamino-6-hydroxypyrimidine (1672-50-0)

Guidance literature:

With polymer-supported carbonate; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 24h;

Reference yield:

→ 4,5-diamino-6-hydroxypyrimidine (1672-50-0)

Guidance literature:

5,6-Diamino-4-hydroxy-pyrimidin-sulfinsaeure-(2), aethanol. HCl, 20 h;

DOI:10.1021/jo01071a611

upstream raw materials:

5,6-diamino-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

6-amino-5-nitro-3H-pyrimidin-4-one

5,6-diamino-3H-pyrimidin-4-one hemisulfonate

Downstream raw materials:

diceto-6,8 purine

6-amino-5-formylamino-3H-pyrimidin-4-one

pteridin-4-one

5-acetylamino-4-amino-6-oxo-1,6-dihydropyrimidine