(R,R)-N-benzyl-N-(1-phenylethyl)-p-chlorobenzenesulfinamide

Base Information

• Chemical Name: (R,R)-N-benzyl-N-(1-phenylethyl)-p-chlorobenzenesulfinamide
• CAS No.: 1307296-53-2
• Molecular Formula: C₂₁H₂₀ClNOS
• Molecular Weight: 369.915
• Mol file: 1307296-53-2.mol

Synonyms:(R,R)-N-benzyl-N-(1-phenylethyl)-p-chlorobenzenesulfinamide

Chemical Property of (R,R)-N-benzyl-N-(1-phenylethyl)-p-chlorobenzenesulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,R)-N-benzyl-N-(1-phenylethyl)-p-chlorobenzenesulfinamide

There total 5 articles about (R,R)-N-benzyl-N-(1-phenylethyl)-p-chlorobenzenesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-chlorophenylsulfinyl chloride (2901-92-0) + (R)-N-benzyl-1-phenylethylamine (38235-77-7) → (R,R)-N-benzyl-N-(1-phenylethyl)-p-chlorobenzenesulfinamide (1307296-53-2) + (R,S)-N-benzyl-N-(1-phenylethyl)-p-chlorobenzenesulfinamide (1307296-49-6)

Guidance literature:

With triethylamine; In toluene; at 0 - 20 ℃; for 2.25h; optical yield given as %de; diastereoselective reaction;

DOI:10.1016/j.tetasy.2011.01.028

Reference yield:

(R,S)-N-Benzyl-N-(1-phenylethyl)-p-toluenesulfinamide (1307296-48-5) → (R,R)-N-benzyl-N-(1-phenylethyl)-p-chlorobenzenesulfinamide (1307296-53-2) + (R,S)-N-benzyl-N-(1-phenylethyl)-p-chlorobenzenesulfinamide (1307296-49-6)

Guidance literature:

Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / methanol; toluene / 155 h / -5 °C

2: triethylamine / toluene / 2.25 h / 0 - 20 °C

With boron trifluoride diethyl etherate; triethylamine; In methanol; toluene;

DOI:10.1016/j.tetasy.2011.01.028

Reference yield:

(R,S)-N-benzyl-N-(1-phenylethyl)-p-fluorobenzenesulfinamide (1307296-50-9) → (R,R)-N-benzyl-N-(1-phenylethyl)-p-chlorobenzenesulfinamide (1307296-53-2) + (R,S)-N-benzyl-N-(1-phenylethyl)-p-chlorobenzenesulfinamide (1307296-49-6)

Guidance literature:

Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / methanol; toluene / 155 h / -5 °C

2: triethylamine / toluene / 2.25 h / 0 - 20 °C

With boron trifluoride diethyl etherate; triethylamine; In methanol; toluene;

DOI:10.1016/j.tetasy.2011.01.028

upstream raw materials:

(R,S)-N-benzyl-N-(1-phenylethyl)benzenesulfinamide

(R,S)-N-Benzyl-N-(1-phenylethyl)-p-toluenesulfinamide

(R,S)-N-benzyl-N-(1-phenylethyl)-p-fluorobenzenesulfinamide

p-chlorophenylsulfinyl chloride