1-(5'-O-t-butyldimethylsilyl-2',3'-dideoxy-3'-phenylselenonyl-β-D-glycero-pent-2'-eno-furanosyl)uracil

Base Information

Chemical Name:1-(5'-O-t-butyldimethylsilyl-2',3'-dideoxy-3'-phenylselenonyl-β-D-glycero-pent-2'-eno-furanosyl)uracil
CAS No.:129928-64-9
Molecular Formula:C₂₁H₂₈N₂O₆SeSi
Molecular Weight:511.509
Hs Code.:

Synonyms:1-(5'-O-t-butyldimethylsilyl-2',3'-dideoxy-3'-phenylselenonyl-β-D-glycero-pent-2'-eno-furanosyl)uracil

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Chemical Property of 1-(5'-O-t-butyldimethylsilyl-2',3'-dideoxy-3'-phenylselenonyl-β-D-glycero-pent-2'-eno-furanosyl)uracil

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Technology Process of 1-(5'-O-t-butyldimethylsilyl-2',3'-dideoxy-3'-phenylselenonyl-β-D-glycero-pent-2'-eno-furanosyl)uracil

There total 8 articles about 1-(5'-O-t-butyldimethylsilyl-2',3'-dideoxy-3'-phenylselenonyl-β-D-glycero-pent-2'-eno-furanosyl)uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 125417-97-2
1-(2',3'-dideoxy-3'phenylselenonyl-β-D-glyceropent-2'-enofuranosyl)uracil

: 18162-48-6
tert-butyldimethylsilyl chloride

: 129928-64-9
1-(5'-O-t-butyldimethylsilyl-2',3'-dideoxy-3'-phenylselenonyl-β-D-glycero-pent-2'-eno-furanosyl)uracil

Guidance literature:: In pyridine; for 5h;
DOI:10.1016/S0040-4020(01)88395-2

Reference yield: 82.0%

: 190723-51-4
1-[(2R,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-phenylselanyl-2,5-dihydro-furan-2-yl]-1H-pyrimidine-2,4-dione

: 129928-64-9
1-(5'-O-t-butyldimethylsilyl-2',3'-dideoxy-3'-phenylselenonyl-β-D-glycero-pent-2'-eno-furanosyl)uracil

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In methanol; at 0 - 25 ℃; for 12h;
DOI:10.1055/s-1997-802

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 129928-64-9
1-(5'-O-t-butyldimethylsilyl-2',3'-dideoxy-3'-phenylselenonyl-β-D-glycero-pent-2'-eno-furanosyl)uracil

Guidance literature:: Multi-step reaction with 6 steps

1: DMAP, pyridine / 2 h / 0 °C

2: pyridine / 2 h / 0 °C

3: 1N NaOH / 3 h / Ambient temperature

4: 1.) LAH; 2.) pyridine / 1.) THF, 0 deg C, 30 min; 2.) 0 deg C to rt., 24 h

5: t-BuOK / dimethylformamide / 0.12 h / 0 °C

6: 82 percent / m-chloroperbenzoic acid / methanol / 12 h / 0 - 25 °C

With pyridine; dmap; sodium hydroxide; lithium aluminium tetrahydride; potassium tert-butylate; 3-chloro-benzenecarboperoxoic acid; In methanol; N,N-dimethyl-formamide;
DOI:10.1055/s-1997-802