1-[(2R,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-phenylselanyl-2,5-dihydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-[(2R,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-phenylselanyl-2,5-dihydro-furan-2-yl]-1H-pyrimidine-2,4-dione
CAS No.:190723-51-4
Molecular Formula:C₂₁H₂₈N₂O₄SeSi
Molecular Weight:479.51
Hs Code.:

Synonyms:1-[(2R,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-phenylselanyl-2,5-dihydro-furan-2-yl]-1H-pyrimidine-2,4-dione

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Chemical Property of 1-[(2R,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-phenylselanyl-2,5-dihydro-furan-2-yl]-1H-pyrimidine-2,4-dione

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Technology Process of 1-[(2R,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-phenylselanyl-2,5-dihydro-furan-2-yl]-1H-pyrimidine-2,4-dione

There total 6 articles about 1-[(2R,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-phenylselanyl-2,5-dihydro-furan-2-yl]-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Methanesulfonic acid (2R,3R,4R,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-phenylselanyl-tetrahydro-furan-3-yl ester

: 190723-51-4
1-[(2R,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-phenylselanyl-2,5-dihydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide; at 0 ℃; for 0.116667h;
DOI:10.1055/s-1997-802

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 190723-51-4
1-[(2R,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-phenylselanyl-2,5-dihydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: DMAP, pyridine / 2 h / 0 °C

2: pyridine / 2 h / 0 °C

3: 1N NaOH / 3 h / Ambient temperature

4: 1.) LAH; 2.) pyridine / 1.) THF, 0 deg C, 30 min; 2.) 0 deg C to rt., 24 h

5: t-BuOK / dimethylformamide / 0.12 h / 0 °C

With pyridine; dmap; sodium hydroxide; lithium aluminium tetrahydride; potassium tert-butylate; In N,N-dimethyl-formamide;
DOI:10.1055/s-1997-802

Reference yield:

: 120649-56-1
1-<2,3-Anhydro-5-(O-tert-butyldimethylsilyl)-β-D-lyxofuranosyl>uracil

: 190723-51-4
1-[(2R,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-phenylselanyl-2,5-dihydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LAH; 2.) pyridine / 1.) THF, 0 deg C, 30 min; 2.) 0 deg C to rt., 24 h

2: t-BuOK / dimethylformamide / 0.12 h / 0 °C

With pyridine; lithium aluminium tetrahydride; potassium tert-butylate; In N,N-dimethyl-formamide;
DOI:10.1055/s-1997-802