N-(4-(2-chloro-6-fluoroquinolin-3-yl)-6-(4-fluorophenyl)pyrimidin-2-yl)-2-morpholinoacetamide

Base Information

Chemical Name:N-(4-(2-chloro-6-fluoroquinolin-3-yl)-6-(4-fluorophenyl)pyrimidin-2-yl)-2-morpholinoacetamide
CAS No.:1414876-15-5
Molecular Formula:C₂₅H₂₀ClF₂N₅O₂
Molecular Weight:495.916
Hs Code.:

Synonyms:N-(4-(2-chloro-6-fluoroquinolin-3-yl)-6-(4-fluorophenyl)pyrimidin-2-yl)-2-morpholinoacetamide

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Chemical Property of N-(4-(2-chloro-6-fluoroquinolin-3-yl)-6-(4-fluorophenyl)pyrimidin-2-yl)-2-morpholinoacetamide

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Technology Process of N-(4-(2-chloro-6-fluoroquinolin-3-yl)-6-(4-fluorophenyl)pyrimidin-2-yl)-2-morpholinoacetamide

There total 5 articles about N-(4-(2-chloro-6-fluoroquinolin-3-yl)-6-(4-fluorophenyl)pyrimidin-2-yl)-2-morpholinoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 110-91-8,99108-56-2
morpholine

: 1414875-97-0
2-chloro-N-(4-(2-chloro-6-fluorochloroquinolin-3-yl)-6-(4-fluorophenyl)pyrimidin-2-yl)acetamide

: 1414876-15-5
N-(4-(2-chloro-6-fluoroquinolin-3-yl)-6-(4-fluorophenyl)pyrimidin-2-yl)-2-morpholinoacetamide

Guidance literature:: With potassium carbonate; In toluene; Reflux; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.09.039

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 1414876-15-5
N-(4-(2-chloro-6-fluoroquinolin-3-yl)-6-(4-fluorophenyl)pyrimidin-2-yl)-2-morpholinoacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / ethanol; water / 24 h / 20 °C

2: sodium hydroxide / ethanol; water / 12 h / Reflux

3: triethylamine / chloroform / 12 h / Reflux; Inert atmosphere

4: potassium carbonate / toluene / Reflux; Inert atmosphere

With potassium carbonate; triethylamine; sodium hydroxide; In ethanol; chloroform; water; toluene; 1: |Claisen-Schmidt Condensation;
DOI:10.1016/j.bmcl.2012.09.039

Reference yield:

: 2-chloro-3-(1-oxo-1-(4-fluoro-phenyl)-prop-2-en-3-yl)-6-fluoroquinoline

: 1414876-15-5
N-(4-(2-chloro-6-fluoroquinolin-3-yl)-6-(4-fluorophenyl)pyrimidin-2-yl)-2-morpholinoacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol; water / 12 h / Reflux

2: triethylamine / chloroform / 12 h / Reflux; Inert atmosphere

3: potassium carbonate / toluene / Reflux; Inert atmosphere

With potassium carbonate; triethylamine; sodium hydroxide; In ethanol; chloroform; water; toluene;
DOI:10.1016/j.bmcl.2012.09.039