2-chloro-N-(4-(2-chloro-6-fluorochloroquinolin-3-yl)-6-(4-fluorophenyl)pyrimidin-2-yl)acetamide

Base Information

• Chemical Name: 2-chloro-N-(4-(2-chloro-6-fluorochloroquinolin-3-yl)-6-(4-fluorophenyl)pyrimidin-2-yl)acetamide
• CAS No.: 1414875-97-0
• Molecular Formula: C₂₁H₁₂Cl₂F₂N₄O
• Molecular Weight: 445.255

Synonyms:2-chloro-N-(4-(2-chloro-6-fluorochloroquinolin-3-yl)-6-(4-fluorophenyl)pyrimidin-2-yl)acetamide

Chemical Property of 2-chloro-N-(4-(2-chloro-6-fluorochloroquinolin-3-yl)-6-(4-fluorophenyl)pyrimidin-2-yl)acetamide

Chemical Property:

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Technology Process of 2-chloro-N-(4-(2-chloro-6-fluorochloroquinolin-3-yl)-6-(4-fluorophenyl)pyrimidin-2-yl)acetamide

There total 4 articles about 2-chloro-N-(4-(2-chloro-6-fluorochloroquinolin-3-yl)-6-(4-fluorophenyl)pyrimidin-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-chloro-3-(2-amino-4-(4-fluorophenyl)pyrimidin-6-yl)-6-fluoroquinoline (1414875-82-3) + chloroacetyl chloride (79-04-9) → 2-chloro-N-(4-(2-chloro-6-fluorochloroquinolin-3-yl)-6-(4-fluorophenyl)pyrimidin-2-yl)acetamide (1414875-97-0)

Guidance literature:

With triethylamine; In chloroform; for 12h; Reflux; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.09.039

Reference yield:

1-(4-fluorophenyl)ethanone (403-42-9) → 2-chloro-N-(4-(2-chloro-6-fluorochloroquinolin-3-yl)-6-(4-fluorophenyl)pyrimidin-2-yl)acetamide (1414875-97-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol; water / 24 h / 20 °C

2: sodium hydroxide / ethanol; water / 12 h / Reflux

3: triethylamine / chloroform / 12 h / Reflux; Inert atmosphere

With triethylamine; sodium hydroxide; In ethanol; chloroform; water; 1: |Claisen-Schmidt Condensation;

DOI:10.1016/j.bmcl.2012.09.039

Reference yield:

2-chloro-6-fluoro-quinoline-3-carboxaldehyde (749920-54-5) → 2-chloro-N-(4-(2-chloro-6-fluorochloroquinolin-3-yl)-6-(4-fluorophenyl)pyrimidin-2-yl)acetamide (1414875-97-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol; water / 24 h / 20 °C

2: sodium hydroxide / ethanol; water / 12 h / Reflux

3: triethylamine / chloroform / 12 h / Reflux; Inert atmosphere

With triethylamine; sodium hydroxide; In ethanol; chloroform; water; 1: |Claisen-Schmidt Condensation;

DOI:10.1016/j.bmcl.2012.09.039

upstream raw materials:

1-(4-fluorophenyl)ethanone

2-chloro-6-fluoro-quinoline-3-carboxaldehyde

2-chloro-3-(2-amino-4-(4-fluorophenyl)pyrimidin-6-yl)-6-fluoroquinoline

chloroacetyl chloride

Downstream raw materials:

N-(4-(2-chloro-6-fluoroquinolin-3-yl)-6-(4-fluorophenyl)pyrimidin-2-yl)-2-morpholinoacetamide

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