2-chloro-3-(2-amino-4-(4-fluorophenyl)pyrimidin-6-yl)-6-fluoroquinoline

Base Information

Chemical Name:2-chloro-3-(2-amino-4-(4-fluorophenyl)pyrimidin-6-yl)-6-fluoroquinoline
CAS No.:1414875-82-3
Molecular Formula:C₁₉H₁₁ClF₂N₄
Molecular Weight:368.773
Hs Code.:

Synonyms:2-chloro-3-(2-amino-4-(4-fluorophenyl)pyrimidin-6-yl)-6-fluoroquinoline

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Chemical Property of 2-chloro-3-(2-amino-4-(4-fluorophenyl)pyrimidin-6-yl)-6-fluoroquinoline

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Technology Process of 2-chloro-3-(2-amino-4-(4-fluorophenyl)pyrimidin-6-yl)-6-fluoroquinoline

There total 4 articles about 2-chloro-3-(2-amino-4-(4-fluorophenyl)pyrimidin-6-yl)-6-fluoroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 2-chloro-3-(1-oxo-1-(4-fluoro-phenyl)-prop-2-en-3-yl)-6-fluoroquinoline

: 506-93-4
guanidine nitrate

: 1414875-82-3
2-chloro-3-(2-amino-4-(4-fluorophenyl)pyrimidin-6-yl)-6-fluoroquinoline

Guidance literature:: With sodium hydroxide; In ethanol; water; for 12h; Reflux;
DOI:10.1016/j.bmcl.2012.09.039

Reference yield: 62.0%

: 2-chloro-3-(1-oxo-1-(4-fluoro-phenyl)-prop-2-en-3-yl)-6-fluoroquinoline

: 50-01-1
guanidine hydrochloride

: 1414875-82-3
2-chloro-3-(2-amino-4-(4-fluorophenyl)pyrimidin-6-yl)-6-fluoroquinoline

Guidance literature:: With potassium carbonate; In ethanol; for 0.166667h; Microwave irradiation;
DOI:10.1111/cbdd.12178

Reference yield:

: 749920-54-5
2-chloro-6-fluoro-quinoline-3-carboxaldehyde

: 1414875-82-3
2-chloro-3-(2-amino-4-(4-fluorophenyl)pyrimidin-6-yl)-6-fluoroquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 24 h

2: potassium carbonate / ethanol / 0.17 h / Microwave irradiation

With potassium carbonate; sodium hydroxide; In ethanol; 1: |Claisen-Schmidt Condensation;
DOI:10.1111/cbdd.12178