5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-3-{2-(methyloxy)-3-[(E)-2-(methyloxy)ethenyl]phenyl}-1,2,4-thiadiazole

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Chemical Name:5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-3-{2-(methyloxy)-3-[(E)-2-(methyloxy)ethenyl]phenyl}-1,2,4-thiadiazole
CAS No.:1344997-89-2
Molecular Formula:C₂₁H₂₁ClN₂O₃S
Molecular Weight:416.928
Hs Code.:

Synonyms:5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-3-{2-(methyloxy)-3-[(E)-2-(methyloxy)ethenyl]phenyl}-1,2,4-thiadiazole

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Chemical Property of 5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-3-{2-(methyloxy)-3-[(E)-2-(methyloxy)ethenyl]phenyl}-1,2,4-thiadiazole

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Technology Process of 5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-3-{2-(methyloxy)-3-[(E)-2-(methyloxy)ethenyl]phenyl}-1,2,4-thiadiazole

There total 6 articles about 5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-3-{2-(methyloxy)-3-[(E)-2-(methyloxy)ethenyl]phenyl}-1,2,4-thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1260023-56-0
3-bromo-5-(3-chloro-4-isopropoxyphenyl)-1,2,4-thiadiazole

: 1344997-88-1
{2-(methyloxy)-3-[(E)-2-(methyloxy)ethenyl]phenyl}boronic acid

: 1344997-89-2
5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-3-{2-(methyloxy)-3-[(E)-2-(methyloxy)ethenyl]phenyl}-1,2,4-thiadiazole

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 120 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 95-56-7
2-hydroxybromobenzene

: 1344997-89-2
5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-3-{2-(methyloxy)-3-[(E)-2-(methyloxy)ethenyl]phenyl}-1,2,4-thiadiazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; magnesium chloride / acetonitrile / 0.33 h / 20 °C

1.2: Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 - 20 °C

3.2: 2 h / -78 °C

4.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

4.2: 0.5 h / -78 °C

5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.17 h / 120 °C / Microwave irradiation

With potassium phosphate; n-butyllithium; potassium carbonate; triethylamine; magnesium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile; 3.2: Wittig Reaction / 5.1: Suzuki Coupling;

Reference yield:

: 480438-56-0
{3-chloro-4-[(1-methylethyl)oxy]phenyl}boronic acid

: 1344997-89-2
5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-3-{2-(methyloxy)-3-[(E)-2-(methyloxy)ethenyl]phenyl}-1,2,4-thiadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; water / 1 h / 80 °C / Inert atmosphere; Microwave irradiation; Sealed vessel

2: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.17 h / 120 °C / Microwave irradiation

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; N,N-dimethyl-formamide; 1: Suzuki Coupling / 2: Suzuki Coupling;