Technology Process of [3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-thiadiazol-3-yl)-2-(methyloxy)phenyl]acetaldehyde
There total 8 articles about [3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-thiadiazol-3-yl)-2-(methyloxy)phenyl]acetaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-3-{2-(methyloxy)-3-[(E)-2-(methyloxy)ethenyl]phenyl}-1,2,4-thiadiazole;
With
chloro-trimethyl-silane; sodium iodide;
In
acetonitrile;
at 20 ℃;
for 16h;
With
water;
In
acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine; magnesium chloride / acetonitrile / 0.33 h / 20 °C
1.2: Reflux
2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
3.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 - 20 °C
3.2: 2 h / -78 °C
4.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere
4.2: 0.5 h / -78 °C
5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 0.17 h / 120 °C / Microwave irradiation
6.1: chloro-trimethyl-silane; sodium iodide / acetonitrile / 16 h / 20 °C
With
potassium phosphate; n-butyllithium; chloro-trimethyl-silane; potassium carbonate; triethylamine; sodium iodide; magnesium chloride;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;
3.2: Wittig Reaction / 5.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide; water / 1 h / 80 °C / Inert atmosphere; Microwave irradiation; Sealed vessel
2: potassium phosphate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 0.17 h / 120 °C / Microwave irradiation
3: chloro-trimethyl-silane; sodium iodide / acetonitrile / 16 h / 20 °C
With
potassium phosphate; chloro-trimethyl-silane; sodium iodide;
tetrakis(triphenylphosphine) palladium(0); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
water; N,N-dimethyl-formamide; acetonitrile;
1: Suzuki Coupling / 2: Suzuki Coupling;
![5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-3-{2-(methyloxy)-3-[(E)-2-(methyloxy)ethenyl]phenyl}-1,2,4-thiadiazole](/Databaselist/images/loading.webp)
