(1R,2R)-methyl-2-(2-fluoro-6-methoxy-4-pentylphenyl)-4-oxocyclohexanecarboxylate

Base Information

Chemical Name:(1R,2R)-methyl-2-(2-fluoro-6-methoxy-4-pentylphenyl)-4-oxocyclohexanecarboxylate
CAS No.:1421319-69-8
Molecular Formula:C₂₀H₂₇FO₄
Molecular Weight:350.43
Hs Code.:

Synonyms:(1R,2R)-methyl-2-(2-fluoro-6-methoxy-4-pentylphenyl)-4-oxocyclohexanecarboxylate

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Chemical Property of (1R,2R)-methyl-2-(2-fluoro-6-methoxy-4-pentylphenyl)-4-oxocyclohexanecarboxylate

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Technology Process of (1R,2R)-methyl-2-(2-fluoro-6-methoxy-4-pentylphenyl)-4-oxocyclohexanecarboxylate

There total 3 articles about (1R,2R)-methyl-2-(2-fluoro-6-methoxy-4-pentylphenyl)-4-oxocyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₂₉FO₅

: 74-88-4
methyl iodide

: 1421319-69-8
(1R,2R)-methyl-2-(2-fluoro-6-methoxy-4-pentylphenyl)-4-oxocyclohexanecarboxylate

Guidance literature:: C₂₁H₂₉FO₅; methyl iodide; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;

With sodium methylate; In methanol; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ol303351y

Reference yield:

: (R)-7-(2-fluoro-6-methoxy-4-pentylphenyl)-8-(methoxymethylene)-1,4-dioxaspiro[4.5]decane

: 1421319-69-8
(1R,2R)-methyl-2-(2-fluoro-6-methoxy-4-pentylphenyl)-4-oxocyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / water / 2 h / 100 °C / Reflux; Inert atmosphere

2.1: Jones reagent / water; acetone / 2 h / 20 °C / Cooling with ice; Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

3.2: 24 h / 20 °C / Inert atmosphere

With Jones reagent; potassium carbonate; acetic acid; In water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol303351y

Reference yield:

: C₂₁H₂₉FO₄

: 1421319-69-8
(1R,2R)-methyl-2-(2-fluoro-6-methoxy-4-pentylphenyl)-4-oxocyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Jones reagent / water; acetone / 2 h / 20 °C / Cooling with ice; Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2.2: 24 h / 20 °C / Inert atmosphere

With Jones reagent; potassium carbonate; In water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol303351y