(cis)-3-(2-fluoro-6-methoxy-4-pentylphenyl)-4-(2-hydroxypropan-2-yl)-1-methylcyclohexanol

Base Information

Chemical Name:(cis)-3-(2-fluoro-6-methoxy-4-pentylphenyl)-4-(2-hydroxypropan-2-yl)-1-methylcyclohexanol
CAS No.:1421319-81-4
Molecular Formula:C₂₂H₃₅FO₃
Molecular Weight:366.517
Hs Code.:

Synonyms:(cis)-3-(2-fluoro-6-methoxy-4-pentylphenyl)-4-(2-hydroxypropan-2-yl)-1-methylcyclohexanol

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Chemical Property of (cis)-3-(2-fluoro-6-methoxy-4-pentylphenyl)-4-(2-hydroxypropan-2-yl)-1-methylcyclohexanol

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Technology Process of (cis)-3-(2-fluoro-6-methoxy-4-pentylphenyl)-4-(2-hydroxypropan-2-yl)-1-methylcyclohexanol

There total 4 articles about (cis)-3-(2-fluoro-6-methoxy-4-pentylphenyl)-4-(2-hydroxypropan-2-yl)-1-methylcyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1421319-69-8
(1R,2R)-methyl-2-(2-fluoro-6-methoxy-4-pentylphenyl)-4-oxocyclohexanecarboxylate

: 75-16-1
methylmagnesium bromide

: 1421319-63-2
(3R,4R)-3-(2-fluoro-6-methoxy-4-pentylphenyl)-4-(2-hydroxypropan-2-yl)-1-methylcyclohexanol

: 1421319-81-4
(cis)-3-(2-fluoro-6-methoxy-4-pentylphenyl)-4-(2-hydroxypropan-2-yl)-1-methylcyclohexanol

Guidance literature:: In tetrahydrofuran; diethyl ether; at 0 ℃; for 3h; Reflux; Inert atmosphere;
DOI:10.1021/ol303351y

Reference yield:

: (R)-7-(2-fluoro-6-methoxy-4-pentylphenyl)-8-(methoxymethylene)-1,4-dioxaspiro[4.5]decane

: 1421319-81-4
(cis)-3-(2-fluoro-6-methoxy-4-pentylphenyl)-4-(2-hydroxypropan-2-yl)-1-methylcyclohexanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / water / 2 h / 100 °C / Reflux; Inert atmosphere

2.1: Jones reagent / water; acetone / 2 h / 20 °C / Cooling with ice; Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

3.2: 24 h / 20 °C / Inert atmosphere

4.1: tetrahydrofuran; diethyl ether / 3 h / 0 °C / Reflux; Inert atmosphere

With Jones reagent; potassium carbonate; acetic acid; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol303351y

Reference yield:

: C₂₁H₂₉FO₄

: 1421319-81-4
(cis)-3-(2-fluoro-6-methoxy-4-pentylphenyl)-4-(2-hydroxypropan-2-yl)-1-methylcyclohexanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: Jones reagent / water; acetone / 2 h / 20 °C / Cooling with ice; Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2.2: 24 h / 20 °C / Inert atmosphere

3.1: tetrahydrofuran; diethyl ether / 3 h / 0 °C / Reflux; Inert atmosphere

With Jones reagent; potassium carbonate; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol303351y